    <SEC-DOCUMENT>0001213900-21-004495-index.html : 20210127
    <SEC-HEADER>0001213900-21-004495.hdr.sgml : 20210127
    <ACCEPTANCE-DATETIME>20210126215117
    ACCESSION NUMBER:		0001213900-21-004495
    CONFORMED SUBMISSION TYPE:	S-4
    PUBLIC DOCUMENT COUNT:		21
    FILED AS OF DATE:		20210127
    DATE AS OF CHANGE:		20210126

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			AYTU BIOSCIENCE, INC
    		CENTRAL INDEX KEY:			0001385818
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				470883144
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-4
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-252450
    		FILM NUMBER:		21556579

    	BUSINESS ADDRESS:
    		STREET 1:		373 INVERNESS PARKWAY
    		STREET 2:		SUITE 206
    		CITY:			ENGLEWOOD
    		STATE:			CO
    		ZIP:			80112
    		BUSINESS PHONE:		(720) 437-6580

    	MAIL ADDRESS:
    		STREET 1:		373 INVERNESS PARKWAY
    		STREET 2:		SUITE 206
    		CITY:			ENGLEWOOD
    		STATE:			CO
    		ZIP:			80112

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC.
    		DATE OF NAME CHANGE:	20150609

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Rosewind CORP
    		DATE OF NAME CHANGE:	20070110
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>S-4
    <SEQUENCE>1
    <FILENAME>ea133601-s4_aytubioscience.htm
    <DESCRIPTION>REGISTRATION STATEMENT
    <TEXT>
    Document 1 - file: ea133601-s4_aytubioscience.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5.1
    <SEQUENCE>2
    <FILENAME>ea133601ex5-1_aytubio.htm
    <DESCRIPTION>OPINION OF DORSEY & WHITNEY LLP
    <TEXT>
    Document 2 - file: ea133601ex5-1_aytubio.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-8.1
    <SEQUENCE>3
    <FILENAME>ea133601ex8-1_aytubio.htm
    <DESCRIPTION>OPINION OF DORSEY & WHITNEY LLP AS TO CERTAIN U.S. FEDERAL INCOME TAX MATTERS
    <TEXT>
    Document 3 - file: ea133601ex8-1_aytubio.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-8.2
    <SEQUENCE>4
    <FILENAME>ea133601ex8-2_aytubio.htm
    <DESCRIPTION>OPINION OF GOODWIN PROCTER LLP AS TO CERTAIN U.S. FEDERAL INCOME TAX MATTERS
    <TEXT>
    Document 4 - file: ea133601ex8-2_aytubio.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-21.1
    <SEQUENCE>5
    <FILENAME>ea133601ex21-1_aytubio.htm
    <DESCRIPTION>SUBSIDIARIES OF THE REGISTRANT
    <TEXT>
    Document 5 - file: ea133601ex21-1_aytubio.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.6
    <SEQUENCE>6
    <FILENAME>ea133601ex23-6_aytubio.htm
    <DESCRIPTION>CONSENT OF PLANTE & MORAN, PLLC RELATING TO AYTU'S FINANCIAL STATEMENTS
    <TEXT>
    Document 6 - file: ea133601ex23-6_aytubio.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.7
    <SEQUENCE>7
    <FILENAME>ea133601ex23-7_aytubio.htm
    <DESCRIPTION>CONSENT OF HALL & COMPANY CERTIFIED PUBLIC ACCOUNTANTS & CONSULTANTS, INC., RELATING TO INNOVUS' FINANCIAL STATEMENTS
    <TEXT>
    Document 7 - file: ea133601ex23-7_aytubio.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.8
    <SEQUENCE>8
    <FILENAME>ea133601ex23-8_aytubio.htm
    <DESCRIPTION>CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS OF THE ABBREVIATED FINANCIAL STATEMENTS OF THE PEDIATRICS PRODUCT PORTFOLIO OF CERECOR INC.
    <TEXT>
    Document 8 - file: ea133601ex23-8_aytubio.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.9
    <SEQUENCE>9
    <FILENAME>ea133601ex23-9_aytubio.htm
    <DESCRIPTION>CONSENT OF RSM US LLP RELATING TO NEOS' FINANCIAL STATEMENTS
    <TEXT>
    Document 9 - file: ea133601ex23-9_aytubio.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.1
    <SEQUENCE>10
    <FILENAME>ea133601ex99-1_aytubio.htm
    <DESCRIPTION>PROXY CARD FOR AYTU
    <TEXT>
    Document 10 - file: ea133601ex99-1_aytubio.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.2
    <SEQUENCE>11
    <FILENAME>ea133601ex99-2_aytubio.htm
    <DESCRIPTION>PROXY CARD FOR NEOS
    <TEXT>
    Document 11 - file: ea133601ex99-2_aytubio.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.3
    <SEQUENCE>12
    <FILENAME>ea133601ex99-3_aytubio.htm
    <DESCRIPTION>CONSENT OF COWEN AND COMPANY, LLC
    <TEXT>
    Document 12 - file: ea133601ex99-3_aytubio.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.4
    <SEQUENCE>13
    <FILENAME>ea133601ex99-4_aytubio.htm
    <DESCRIPTION>CONSENT OF MTS HEALTH PARTNERS, L.P.
    <TEXT>
    Document 13 - file: ea133601ex99-4_aytubio.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>img_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 14 - file: img_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>15
    <FILENAME>img_002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 15 - file: img_002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>16
    <FILENAME>img_003.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 16 - file: img_003.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>17
    <FILENAME>img_004.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 17 - file: img_004.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>18
    <FILENAME>ex99-1_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 18 - file: ex99-1_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>19
    <FILENAME>ex99-1_002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 19 - file: ex99-1_002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>20
    <FILENAME>ex99-2_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 20 - file: ex99-2_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>21
    <FILENAME>ex99-2_002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 21 - file: ex99-2_002.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>