<SEC-DOCUMENT>0001213900-21-004495-index.html : 20210127
<SEC-HEADER>0001213900-21-004495.hdr.sgml : 20210127
<ACCEPTANCE-DATETIME>20210126215117
ACCESSION NUMBER:		0001213900-21-004495
CONFORMED SUBMISSION TYPE:	S-4
PUBLIC DOCUMENT COUNT:		21
FILED AS OF DATE:		20210127
DATE AS OF CHANGE:		20210126

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AYTU BIOSCIENCE, INC
		CENTRAL INDEX KEY:			0001385818
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				470883144
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-4
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-252450
		FILM NUMBER:		21556579

	BUSINESS ADDRESS:	
		STREET 1:		373 INVERNESS PARKWAY
		STREET 2:		SUITE 206
		CITY:			ENGLEWOOD
		STATE:			CO
		ZIP:			80112
		BUSINESS PHONE:		(720) 437-6580

	MAIL ADDRESS:	
		STREET 1:		373 INVERNESS PARKWAY
		STREET 2:		SUITE 206
		CITY:			ENGLEWOOD
		STATE:			CO
		ZIP:			80112

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC.
		DATE OF NAME CHANGE:	20150609

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Rosewind CORP
		DATE OF NAME CHANGE:	20070110
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-4
<SEQUENCE>1
<FILENAME>ea133601-s4_aytubioscience.htm
<DESCRIPTION>REGISTRATION STATEMENT
<TEXT>
Document 1 - file: ea133601-s4_aytubioscience.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>ea133601ex5-1_aytubio.htm
<DESCRIPTION>OPINION OF DORSEY & WHITNEY LLP
<TEXT>
Document 2 - file: ea133601ex5-1_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-8.1
<SEQUENCE>3
<FILENAME>ea133601ex8-1_aytubio.htm
<DESCRIPTION>OPINION OF DORSEY & WHITNEY LLP AS TO CERTAIN U.S. FEDERAL INCOME TAX MATTERS
<TEXT>
Document 3 - file: ea133601ex8-1_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-8.2
<SEQUENCE>4
<FILENAME>ea133601ex8-2_aytubio.htm
<DESCRIPTION>OPINION OF GOODWIN PROCTER LLP AS TO CERTAIN U.S. FEDERAL INCOME TAX MATTERS
<TEXT>
Document 4 - file: ea133601ex8-2_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-21.1
<SEQUENCE>5
<FILENAME>ea133601ex21-1_aytubio.htm
<DESCRIPTION>SUBSIDIARIES OF THE REGISTRANT
<TEXT>
Document 5 - file: ea133601ex21-1_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.6
<SEQUENCE>6
<FILENAME>ea133601ex23-6_aytubio.htm
<DESCRIPTION>CONSENT OF PLANTE & MORAN, PLLC RELATING TO AYTU'S FINANCIAL STATEMENTS
<TEXT>
Document 6 - file: ea133601ex23-6_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.7
<SEQUENCE>7
<FILENAME>ea133601ex23-7_aytubio.htm
<DESCRIPTION>CONSENT OF HALL & COMPANY CERTIFIED PUBLIC ACCOUNTANTS & CONSULTANTS, INC., RELATING TO INNOVUS' FINANCIAL STATEMENTS
<TEXT>
Document 7 - file: ea133601ex23-7_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.8
<SEQUENCE>8
<FILENAME>ea133601ex23-8_aytubio.htm
<DESCRIPTION>CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS OF THE ABBREVIATED FINANCIAL STATEMENTS OF THE PEDIATRICS PRODUCT PORTFOLIO OF CERECOR INC.
<TEXT>
Document 8 - file: ea133601ex23-8_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.9
<SEQUENCE>9
<FILENAME>ea133601ex23-9_aytubio.htm
<DESCRIPTION>CONSENT OF RSM US LLP RELATING TO NEOS' FINANCIAL STATEMENTS
<TEXT>
Document 9 - file: ea133601ex23-9_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>10
<FILENAME>ea133601ex99-1_aytubio.htm
<DESCRIPTION>PROXY CARD FOR AYTU
<TEXT>
Document 10 - file: ea133601ex99-1_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.2
<SEQUENCE>11
<FILENAME>ea133601ex99-2_aytubio.htm
<DESCRIPTION>PROXY CARD FOR NEOS
<TEXT>
Document 11 - file: ea133601ex99-2_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.3
<SEQUENCE>12
<FILENAME>ea133601ex99-3_aytubio.htm
<DESCRIPTION>CONSENT OF COWEN AND COMPANY, LLC
<TEXT>
Document 12 - file: ea133601ex99-3_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.4
<SEQUENCE>13
<FILENAME>ea133601ex99-4_aytubio.htm
<DESCRIPTION>CONSENT OF MTS HEALTH PARTNERS, L.P.
<TEXT>
Document 13 - file: ea133601ex99-4_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>14
<FILENAME>img_001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 14 - file: img_001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>15
<FILENAME>img_002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 15 - file: img_002.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>16
<FILENAME>img_003.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 16 - file: img_003.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>17
<FILENAME>img_004.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 17 - file: img_004.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>18
<FILENAME>ex99-1_001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 18 - file: ex99-1_001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>19
<FILENAME>ex99-1_002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 19 - file: ex99-1_002.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>20
<FILENAME>ex99-2_001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 20 - file: ex99-2_001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>21
<FILENAME>ex99-2_002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 21 - file: ex99-2_002.jpg

</DOCUMENT>
</SEC-DOCUMENT>