<SEC-DOCUMENT>0001558370-21-012833-index.html : 20210928
<SEC-HEADER>0001558370-21-012833.hdr.sgml : 20210928
<ACCEPTANCE-DATETIME>20210928165633
ACCESSION NUMBER:		0001558370-21-012833
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20210928
DATE AS OF CHANGE:		20210928

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AYTU BIOPHARMA, INC
		CENTRAL INDEX KEY:			0001385818
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				470883144
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-259862
		FILM NUMBER:		211287898

	BUSINESS ADDRESS:	
		STREET 1:		373 INVERNESS PARKWAY
		STREET 2:		SUITE 206
		CITY:			ENGLEWOOD
		STATE:			CO
		ZIP:			80112
		BUSINESS PHONE:		(720) 437-6580

	MAIL ADDRESS:	
		STREET 1:		373 INVERNESS PARKWAY
		STREET 2:		SUITE 206
		CITY:			ENGLEWOOD
		STATE:			CO
		ZIP:			80112

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC
		DATE OF NAME CHANGE:	20150609

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC.
		DATE OF NAME CHANGE:	20150609

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Rosewind CORP
		DATE OF NAME CHANGE:	20070110
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3
<SEQUENCE>1
<FILENAME>tmb-20210928xs3.htm
<DESCRIPTION>S-3
<TEXT>
Document 1 - file: tmb-20210928xs3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.17
<SEQUENCE>2
<FILENAME>tmb-20210928xex4d17.htm
<DESCRIPTION>EX-4.17
<TEXT>
Document 2 - file: tmb-20210928xex4d17.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>tmb-20210928xex5d1.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 3 - file: tmb-20210928xex5d1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>4
<FILENAME>tmb-20210928xex23d2.htm
<DESCRIPTION>EX-23.2
<TEXT>
Document 4 - file: tmb-20210928xex23d2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.3
<SEQUENCE>5
<FILENAME>tmb-20210928xex23d3.htm
<DESCRIPTION>EX-23.3
<TEXT>
Document 5 - file: tmb-20210928xex23d3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>tmb-20210928xs3002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: tmb-20210928xs3002.jpg

</DOCUMENT>
</SEC-DOCUMENT>