    <SEC-DOCUMENT>0001104659-22-043439-index.html : 20220407
    <SEC-HEADER>0001104659-22-043439.hdr.sgml : 20220407
    <ACCEPTANCE-DATETIME>20220407080944
    ACCESSION NUMBER:		0001104659-22-043439
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		3
    CONFORMED PERIOD OF REPORT:	20220518
    FILED AS OF DATE:		20220407
    DATE AS OF CHANGE:		20220407

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			AYTU BIOPHARMA, INC
    		CENTRAL INDEX KEY:			0001385818
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				470883144
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			0630

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-38247
    		FILM NUMBER:		22812348

    	BUSINESS ADDRESS:
    		STREET 1:		373 INVERNESS PARKWAY
    		STREET 2:		SUITE 206
    		CITY:			ENGLEWOOD
    		STATE:			CO
    		ZIP:			80112
    		BUSINESS PHONE:		(720) 437-6580

    	MAIL ADDRESS:
    		STREET 1:		373 INVERNESS PARKWAY
    		STREET 2:		SUITE 206
    		CITY:			ENGLEWOOD
    		STATE:			CO
    		ZIP:			80112

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC
    		DATE OF NAME CHANGE:	20150609

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC.
    		DATE OF NAME CHANGE:	20150609

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Rosewind CORP
    		DATE OF NAME CHANGE:	20070110
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEF 14A
    <SEQUENCE>1
    <FILENAME>tm2210624-1_def14a.htm
    <DESCRIPTION>DEF 14A
    <TEXT>
    Document 1 - file: tm2210624-1_def14a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>tm2210624d1-px_01proxybw.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: tm2210624d1-px_01proxybw.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>tm2210624d1-px_02proxy4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: tm2210624d1-px_02proxy4c.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>