<SEC-DOCUMENT>0000912282-23-000130.txt : 20230615
<SEC-HEADER>0000912282-23-000130.hdr.sgml : 20230615
<ACCEPTANCE-DATETIME>20230615104250
ACCESSION NUMBER:		0000912282-23-000130
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20230613
FILED AS OF DATE:		20230615
DATE AS OF CHANGE:		20230615

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			JAIN ABHINAV
		CENTRAL INDEX KEY:			0001981291

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38247
		FILM NUMBER:		231016289

	MAIL ADDRESS:	
		STREET 1:		C/O AYTU BIOPHARMA, INC.
		STREET 2:		373 INVERNESS PARKWAY, SUITE 206
		CITY:			ENGLEWOOD
		STATE:			CO
		ZIP:			80112

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AYTU BIOPHARMA, INC
		CENTRAL INDEX KEY:			0001385818
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				470883144
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	BUSINESS ADDRESS:	
		STREET 1:		373 INVERNESS PARKWAY
		STREET 2:		SUITE 206
		CITY:			ENGLEWOOD
		STATE:			CO
		ZIP:			80112
		BUSINESS PHONE:		(720) 437-6580

	MAIL ADDRESS:	
		STREET 1:		373 INVERNESS PARKWAY
		STREET 2:		SUITE 206
		CITY:			ENGLEWOOD
		STATE:			CO
		ZIP:			80112

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC
		DATE OF NAME CHANGE:	20150609

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC.
		DATE OF NAME CHANGE:	20150609

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Rosewind CORP
		DATE OF NAME CHANGE:	20070110
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form3.xml
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<ownershipDocument>

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    <periodOfReport>2023-06-13</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001385818</issuerCik>
        <issuerName>AYTU BIOPHARMA, INC</issuerName>
        <issuerTradingSymbol>AYTU</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001981291</rptOwnerCik>
            <rptOwnerName>JAIN ABHINAV</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O AYTU BIOPHARMA, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>373 INVERNESS PARKWAY, SUITE 206</rptOwnerStreet2>
            <rptOwnerCity>ENGLEWOOD</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80112</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>Exhibit 24.1 Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Mark Oki as attorney-in-fact for Abhinav Jain</signatureName>
        <signatureDate>2023-06-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
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<DOCUMENT>
<TYPE>EX-24.1
<SEQUENCE>2
<FILENAME>jainpoa.htm
<DESCRIPTION>POWER OF ATTORNEY
<TEXT>
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  <div style="text-align: center; margin-top: 12pt; margin-bottom: 12pt; font-weight: bold;">LIMITED POWER OF ATTORNEY FOR REPORTING UNDER SECTION 16(a) OF THE SECURITIES EXCHANGE ACT OF 1934,
    AS AMENDED</div>
  <div style="text-indent: 36pt; margin-top: 12pt; margin-bottom: 12pt;">Know all by these presents, that the undersigned hereby constitutes and appoints Jake Siciliano, Fei
    Gao and Mark Oki, each acting alone, as the undersigned&#8217;s true and lawful attorney-in-fact to:</div>
  <table cellspacing="0" cellpadding="0" id="z48cf50a4ac2d4c8880c3751b5f697b49" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000; margin-bottom: 12pt; margin-top: 12pt;">

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        </td>
        <td style="width: 72pt; vertical-align: top;">(1)</td>
        <td style="width: auto; vertical-align: top;">
          <div>execute for and on behalf of the undersigned, in the undersigned&#8217;s capacity as a director or officer of AYTU BioPharma, Inc., a Delaware corporation (&#8220;AYTU&#8221;), Forms&#160;3, 4
            and 5 in accordance with Section&#160;16(a) of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), and the rules and regulations of the United States Securities and Exchange Commission (the &#8220;SEC&#8221;) promulgated thereunder;</div>
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        <td style="width: 72pt; vertical-align: top;">(2)</td>
        <td style="width: auto; vertical-align: top;">
          <div>do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Forms 3, 4 and 5, complete and
            execute any amendment or amendments thereto, and to timely file any such form with the SEC and any stock exchange or similar authority, including completing and executing a Uniform Application for Access Codes to File on Edgar on Form ID; and</div>
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        <td style="width: 72pt; vertical-align: top;">(3)</td>
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          <div>take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest
            of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and
            conditions as such attorney-in-fact may approve in such attorney-in-fact&#8217;s discretion.</div>
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  </table>
  <div style="margin-top: 12pt; margin-bottom: 12pt;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act
    and thing whatsoever requisite, necessary, or proper to be done in the exercise of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or
    revocation, hereby ratifying and confirming all that such attorney-in-fact shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted. The undersigned acknowledges that neither AYTU nor the
    foregoing attorney-in-fact, in serving in such capacity at the request of the undersigned, are not assuming any liability for the undersigned&#8217;s responsibility to comply with the requirements of Section 13 or Section 16 or the Exchange Act or Rule 144,
    any liability of the undersigned for any failure to comply with such requirements, or any liability of the undersigned for disgorgement of profits under Section 16(b) of the Exchange Act.</div>
  <div style="margin-top: 12pt; margin-bottom: 12pt;">The undersigned agrees that each such attorney-in-fact herein may rely entirely on information furnished orally or in
    writing by the undersigned to such attorney-in-fact. The undersigned also agrees to indemnify and hold harmless AYTU and such attorney-in-fact against any losses, claims, damages or liabilities (or actions in these respects) that arise out of or are
    based on any untrue statements or omission of necessary facts in the information provided by the undersigned to such attorney-in fact for purposes of executing, acknowledging, delivering and filing Forms 3, 4 or 5 (including amendments thereto) and
    agrees to reimburse AYTU and such attorney-in-fact for any legal or other expenses reasonably incurred in connection with investigating or defending against any such loss, claim, damage, liability or action.</div>
  <div style="margin-top: 12pt; margin-bottom: 12pt;">This Power of Attorney supersedes any power of attorney previously executed by the undersigned regarding the purposes
    outlined in the first paragraph hereof (&#8220;Prior Powers of Attorney&#8221;), and the authority of the attorneys-in-fact named in any Prior Powers of Attorney is hereby revoked.</div>
  <div style="margin-top: 12pt; margin-bottom: 12pt;">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Forms&#160;3,
    4 and 5 with respect to the undersigned&#8217;s holdings of and transactions in securities issued by AYTU, unless earlier&#160;revoked by the undersigned in a signed writing delivered to the foregoing attorneys-in-fact. This Power of Attorney may be filed with
    the SEC as a confirming statement of authority granted herein.</div>
  <div style="margin-top: 12pt; margin-bottom: 12pt;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 13th day of June, 2023.</div>
  <div style="margin-left: 252pt;"><u>/s/ Abhinav Jain</u><font class="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 12pt">&#160;</font></div>
  <div style="margin-left: 252pt;">Abhinav Jain</div>
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