<SEC-DOCUMENT>0001104659-23-068133-index.html : 20230605
<SEC-HEADER>0001104659-23-068133.hdr.sgml : 20230605
<ACCEPTANCE-DATETIME>20230605172434
ACCESSION NUMBER:		0001104659-23-068133
CONFORMED SUBMISSION TYPE:	S-1/A
PUBLIC DOCUMENT COUNT:		9
FILED AS OF DATE:		20230605
DATE AS OF CHANGE:		20230605

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AYTU BIOPHARMA, INC
		CENTRAL INDEX KEY:			0001385818
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				470883144
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	FILING VALUES:
		FORM TYPE:		S-1/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-271556
		FILM NUMBER:		23993914

	BUSINESS ADDRESS:	
		STREET 1:		373 INVERNESS PARKWAY
		STREET 2:		SUITE 206
		CITY:			ENGLEWOOD
		STATE:			CO
		ZIP:			80112
		BUSINESS PHONE:		(720) 437-6580

	MAIL ADDRESS:	
		STREET 1:		373 INVERNESS PARKWAY
		STREET 2:		SUITE 206
		CITY:			ENGLEWOOD
		STATE:			CO
		ZIP:			80112

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC
		DATE OF NAME CHANGE:	20150609

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC.
		DATE OF NAME CHANGE:	20150609

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Rosewind CORP
		DATE OF NAME CHANGE:	20070110
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-1/A
<SEQUENCE>1
<FILENAME>tm2313999-3_s1a.htm
<DESCRIPTION>S-1/A
<TEXT>
Document 1 - file: tm2313999-3_s1a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.10
<SEQUENCE>2
<FILENAME>tm2313999d4_ex4-10.htm
<DESCRIPTION>EXHIBIT 4.10
<TEXT>
Document 2 - file: tm2313999d4_ex4-10.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.11
<SEQUENCE>3
<FILENAME>tm2313999d4_ex4-11.htm
<DESCRIPTION>EXHIBIT 4.11
<TEXT>
Document 3 - file: tm2313999d4_ex4-11.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.12
<SEQUENCE>4
<FILENAME>tm2313999d4_ex4-12.htm
<DESCRIPTION>EXHIBIT 4.12
<TEXT>
Document 4 - file: tm2313999d4_ex4-12.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>5
<FILENAME>tm2313999d4_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 5 - file: tm2313999d4_ex5-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.42
<SEQUENCE>6
<FILENAME>tm2313999d4_ex10-42.htm
<DESCRIPTION>EXHIBIT 10.42
<TEXT>
Document 6 - file: tm2313999d4_ex10-42.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.43
<SEQUENCE>7
<FILENAME>tm2313999d4_ex10-43.htm
<DESCRIPTION>EXHIBIT 10.43
<TEXT>
Document 7 - file: tm2313999d4_ex10-43.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>8
<FILENAME>tm2313999d4_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 8 - file: tm2313999d4_ex23-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>9
<FILENAME>lg_aytubiopharma-4clr.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 9 - file: lg_aytubiopharma-4clr.jpg

</DOCUMENT>
</SEC-DOCUMENT>