    <SEC-DOCUMENT>0001437749-25-009848-index.html : 20250328
    <SEC-HEADER>0001437749-25-009848.hdr.sgml : 20250328
    <ACCEPTANCE-DATETIME>20250328160806
    ACCESSION NUMBER:		0001437749-25-009848
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20240630
    FILED AS OF DATE:		20250328
    DATE AS OF CHANGE:		20250328
    EFFECTIVENESS DATE:		20250328

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			AYTU BIOPHARMA, INC
    		CENTRAL INDEX KEY:			0001385818
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				470883144
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			0630

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-38247
    		FILM NUMBER:		25786031

    	BUSINESS ADDRESS:
    		STREET 1:		7900 E. UNION AVENUE
    		STREET 2:		SUITE 920
    		CITY:			DENVER
    		STATE:			CO
    		ZIP:			80237
    		BUSINESS PHONE:		(720) 437-6580

    	MAIL ADDRESS:
    		STREET 1:		7900 E. UNION AVENUE
    		STREET 2:		SUITE 920
    		CITY:			DENVER
    		STATE:			CO
    		ZIP:			80237

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC
    		DATE OF NAME CHANGE:	20150609

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC.
    		DATE OF NAME CHANGE:	20150609

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Rosewind CORP
    		DATE OF NAME CHANGE:	20070110
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>aytuars.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: aytuars.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>