<SEC-DOCUMENT>0001437749-25-019196.txt : 20250707
<SEC-HEADER>0001437749-25-019196.hdr.sgml : 20250707
<ACCEPTANCE-DATETIME>20250602175320
<PRIVATE-TO-PUBLIC>
ACCESSION NUMBER:		0001437749-25-019196
CONFORMED SUBMISSION TYPE:	CORRESP
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20250602

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AYTU BIOPHARMA, INC
		CENTRAL INDEX KEY:			0001385818
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				470883144
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	FILING VALUES:
		FORM TYPE:		CORRESP

	BUSINESS ADDRESS:	
		STREET 1:		7900 E. UNION AVENUE
		STREET 2:		SUITE 920
		CITY:			DENVER
		STATE:			CO
		ZIP:			80237
		BUSINESS PHONE:		(720) 437-6580

	MAIL ADDRESS:	
		STREET 1:		7900 E. UNION AVENUE
		STREET 2:		SUITE 920
		CITY:			DENVER
		STATE:			CO
		ZIP:			80237

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC
		DATE OF NAME CHANGE:	20150609

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC.
		DATE OF NAME CHANGE:	20150609

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Rosewind CORP
		DATE OF NAME CHANGE:	20070110
</SEC-HEADER>
<DOCUMENT>
<TYPE>CORRESP
<SEQUENCE>1
<FILENAME>filename1.htm
<TEXT>
<html><head>
	<title>aytu20250602_corresp.htm</title>

	<!-- Generated by ThunderDome Portal - 6/2/2025 9:25:55 PM --><meta charset="utf-8"><meta name="format-detection" content="telephone=no">
</head>
<body style="font-size:10pt;font-family:'Times New Roman';padding:0in .1in;">
<p style="text-align:center;font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<div style="text-align: center;"><img alt="logo.jpg" src="logo.jpg"></div>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>AYTU BIOPHARMA, INC.</b></p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>7900 East Union Avenue, Suite 920</b><br>
<b>Denver, Colorado 80237</b><br>
<b>(720) 437-6580</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">June 2, 2025</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><b>VIA EDGAR</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">United States</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Securities and Exchange Commission</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Division of Corporate Finance</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">100 F Street, N.E.</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Washington, D.C. 20549</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="width: 100%; text-indent: 0px;">

		<tr style="vertical-align: top;">
			<td style="width: 36pt;">&nbsp;</td>
			<td style="width: 36pt;">
			<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">Re:</p>
			</td>
			<td style="width: auto;">
			<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;"><u>Aytu BioPharma, Inc.</u><u>&#8212;</u><u>Registration Statement on Form S-1 (File No. 333-287728</u><u>)</u></p>
			</td>
		</tr>

</table>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Ladies and Gentlemen:</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: justify; margin: 0pt; text-indent: 36pt;">In accordance with Rule 461 under the Securities Act of 1933, as amended, we hereby request acceleration of the effective date of the Registration Statement on Form S-1 (File No. 333-287728) (the &#8220;Registration Statement&#8221;) of Aytu BioPharma, Inc. (the &#8220;Company&#8221;). We respectfully request that the Registration Statement be declared effective as of 5:00 p.m., Eastern Time, on June 4, 2025, or as soon as practicable thereafter. Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Dorsey &amp; Whitney LLP, by calling Josh Erekson at (801) 933-4083.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Very truly yours,</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">AYTU BIOPHARMA, INC.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><u>/s/ Joshua R. Disbrow</u><u>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Name: Joshua R. Disbrow</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Title: Chief Executive Officer</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<div class="LAST-PAGE-BREAK">
<div class="PGFTR">
<div class="hf-row">
<div class="hf-cell PGNUM">&nbsp;</div>
</div>
</div>
</div>


</body></html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>logo.jpg
<TEXT>
begin 644 logo.jpg
M_]C_X  02D9)1@ ! 0$ 8 !@  #_VP!#  ," @," @,# P,$ P,$!0@%!00$
M!0H'!P8(# H,# L*"PL-#A(0#0X1#@L+$!80$1,4%145# \7&!84&!(4%13_
MVP!# 0,$! 4$!0D%!0D4#0L-%!04%!04%!04%!04%!04%!04%!04%!04%!04
M%!04%!04%!04%!04%!04%!04%!04%!3_P  1"  ] ,D# 2(  A$! Q$!_\0
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M <G H$W8YKX@^/+7X?\ AJYU:XC$[)\L4&_:97/1<X./K@X%?+_B+_@H-?\
MA>[\F^^&I56/R2KK64<>Q^S_ *59^/WC[_A+_%ATZUEWZ;IK&-=I^627HS?A
MT'XUY%K&C6FN6+VMY")H7'0]CZCT-?68++:4J:E7C=OU/R7,^+:M#'.E0?[N
M.C.__P"'E@_Z)T?_  =?_<].C_X*4&:18X_APSNQP%76LD_^2]?(WBWP'>^'
M-52WB5KFVG;$$H'Z'T(KJ?"_A&/28P[ 273#YI#V]A7C<0X[*LBH<THWF]E=
M_CJ?J?">7YAQ1-3I3M26\K+[O4^]_@?^U!#\7=8ETN^T >'+[R_,@C-]]H\T
M#J,^6F"/3FO<PV17YI>&+^[\,ZU9:I8N8[JTD$B,/;J#['I7Z%> _&%MXV\,
M6.JVI&V>,%DSDH_\2GZ&OS_),[69N4*FDET\C[[B3(8Y1*$J-W!KKW_X)TE%
M(.:#TKZT^)$=UC4LS!5 R2QP!4,.H6MRVV&YAE;KM20$_I7Q1_P5!_:-_P"%
M:_"^'P)HUV8?$/B<$3M$V'@LE/SMD="Y^4?\"]*^"? .N?$/]CKXI?#KQKKL
M=[%9ZI:1ZBMK-,[K<V,AVR(03PX7#8[$KZT#L?NK17/:;X[T/4?!$'BV+4(C
MX>ELQ?K?$_(("F_>3Z <FL?P)\<? 'Q/U">Q\)^+M*\07D$8EE@L;@2.B9QN
M(],T".YHHJIJNJV>AZ=<ZAJ%S'9V5M&TTUQ,VU(T49+$]@!0!:/Y4<9KYU^+
M7[6_PJN/A;XM71/B9HG]L-I5S]B-K>@2^=Y3;-F.=V[&/>OD+_@G/^U5):>)
MO&+?%CXFW#6ALX!8_P#"1:BSKOWG=LW'KC&<4#L?J117EFC?M1_";Q#JUGI>
MF?$'0;[4;R58;>VANPSRNQP%4=R36KXQ^/?P\^'VO)HGB3QAI.BZLZ*ZV=Y<
M!)"K?=.#ZT".^HID4BS1K(C!D<!E([@TXG H 6BO/M$^/_PZ\2>+1X7TOQEI
M%]XA\UX?[-@N TV],[UV^HP<_2O0: "BBB@ KRKX_P#Q*3P#X1DC@E"ZK?9A
MMP#RH_B?\!^I%>J'I7Y]_M+>,M2O_C#JUCJP-F;(B*TA<_*8>JNI[[NI_+M7
MIY?AU7KI2V1\=Q5F<\LR^4Z:]Z6B\C$75 .XSW)H;5 >XSZ5QW]HM_>X^E>K
M?LW^!3\1?B!"URF_2]- N;@$<,<_(GXGGZ U]K6G&A3<WT/YYP,*N8XJ&'AO
M)GNGPQ^ -CJGP^NG\16H>^U:$% R_-:IU4CT;H3^5?-GBKP->>!_$EYH]\F)
MH'^5\<2)_"P]B*_16*,1H%48 KQ']ICX?)K6@1^(+:+_ $S3Q^]('+1'KGZ=
M?SK\(XMP<LQH2Q4?CC^1_<' V+CD,H8!?PY:?/O\SY1MK/!'%>X?LX>/O^$:
M\0-H5W+ML;\YB+'A)?3\?YXKR!-H7CI5>[UB#2-L\ERL#H0R'/S9'3 ZU^)9
M9CJV#QD*U/=/;R/W#-,%#,L+.A/JM/4_15'#*#VK-\4^(]/\(>'=2UO5;A;7
M3=/MWN;B9C@(B@DG]*R/AMJ^H:YX*T>^U*!K>[GMU=XV&#TX)';(P<>]?#__
M  58_:*;0?#EC\*=%N"M_JX6[U9HFY2V!^2(^[L,D>B^]?TM2G[6G&=K71_-
M=2FZ=1TWT=CYW^%^D:E_P4 _;0N=<U>*1O#-O.+VYB8Y6"PB;$,'MN. 1WRU
M?=O_  4!_9TC^-7P%N)-(LU;Q%X94WVG)&O+QJO[V$?5!P/517YU_LV_M$_%
M/]F/0]3LO"GP[CO&U299[B]U#2+IYG"C"("I VC)('JQKV)_^"E7[0KJ5/PW
ML"#ZZ+>__%5L39GHG_!*WX]Q^*?"6K?"#Q#*)Y].1[G3([@Y\RT8XEAP>H5C
MG'HYKP#XFZ!J?_!/G]LNTUW1HI!X7N9C>6L:\+-82MB:W)[E.0/HAKP_2/B1
MXJ^%OQMLOB7%H$OAF_&IM?I8BVEM[=@S$RPH'YV$,PQDX!]J_4?]JKX9Z/\
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M )A]A_Z&:_8&OQ^_X*A'['^UOI<\P*0G3+)PYZ8$AR?TH$GJ?KIHO_(&L/\
MKWC_ /015VLWPW=17OAW2[B%Q)#+:Q.CCHRE 0:N7EW#I]K+<W,J06\*&226
M1MJHH&223T  H)/QS_94 _X>/Y  /]N:M_[6K]DJ_&3]D'4[;6_^"AEKJ%E*
ML]G=:OJD\,J]'1EE*D?4&OV;H*D%%%%!(5\O?MM_!K_A,/""^+=.@W:MHJDS
M*@YEMNK?]\_>^F:^H:KW=K'=P20S()(G4JR,,A@1R#6]"K*A44X]#S<QP4,P
MPT\/46Z/QR@U2ZMP-DQV^C<BOK3]FOX@WOPZ\&-*NG6US-J4GVAW<E6P.%''
ML/UKQ;]HWX02?"?XFW6GV\9&C7Y^TZ>_8(QYCSZJ>/IBO7M(LUT[2K2U4 "&
M)4P!Z"O"X^SVK@L'1CA96<W?Y(_,^#LG=#,JTJT=:>GWGN)_:8GBB!;0E9O]
MF?C^5<OXJ_:<U&^T^YLUT"T\J=&C;S96;@C'3%>?3#='7/ZO$&!ZU^,4>(LQ
MK>Y4J:/R/V6?[MJ4>AY5J_BG51=36_G+;JCD8B7'';FO0/V:?A9+\5?B%'<7
MZO-I&F%;BZ9^1(P/R1Y]SR?85Y[XCTN:Y\1QV]M$TL]T42.-1RSDX 'U-?H?
M\!?A9#\+/ -EIVQ3?RCS[R4?QRD<CZ#H/I7T^19=#$5E4Y?=6K/V_-N((T,C
MI2I/]Y5C;T[L[#Q/K2^$/">I:J+.YOA86KSBSLH6EFE*J2$1%!+$]  *_*KX
M"_ #XA_M,?M=3>-?B;X3UK1-'2Z;6+K^V-/FMXY C#R+9/,4 @?+D#LIK];P
M!Q2XK]5V/PJ[&I$B*%"* !@ "EV+_='Y4ZBF(^>/VX_V>(_V@_@=J=C9VXD\
M2Z3G4=)95^9I5'S1?1UROUVU\^_\$P-?^(/@J'6/AOXS\'>)-&T@[M0TJ^U+
M2IX88WS^]A+NH SPP&>?FK]"",UP'QV^+6G_  1^%VN^+M01IQ80$P6R EKB
M8\1Q@#U8CZ#)H'?H?D-^W_\ "G1_ _[4FJ:7X1ECN7UP1WCZ9:CFVN9CS%@?
MWCA@/]JOU*_8\^ 5O^SQ\$]'\/M$HUJX7[;JLPZO<N!N&?10 H_W:^&/^"?/
MP=UKX_?'G7OC/XYADN(M.O&N(C<(0)[]^0 #_#$I&/?;Z&OTR\0^.+'PSJ%M
M836NH7=W<1/,D5A:/<-L4@,Q"@XY8?G0#+/C;PU#XR\(:UH-PQ2#4[.:S=AU
M"R(5)_6OQCT _&/_ ()Y?%W4;U- D:VE#6CRW%N\FGZC!NRI61> >AZY'<5^
MQMO\2] N;,7:WNVU^R-?&62-E"Q*VQL@C((;C;USVJI;_$[0;S[0MS#?6#16
MKW@CU&R>$S0H,LR!A\V!U Y'I0"9\1_ K]MOX[_'SXL^&(;#X<I9^!_M035I
M[2VD9!$006-Q)A1M)#;1R<5Z%_P46_9&U?\ :"\-Z5XG\)0"Z\5Z%&\1L2P4
MWELQW%%)XWJV2 >N2*^E;;XM>'O(+RQW^G@1+.B7EC)"98V95#)N&&&67..F
M174OK=JFM)I3,1>/;FY"[>-@8*3GZD4 ?DC\+_V_OC/^SAH=MX)\4^#CJZ::
M@@MHM<@FM+N%!P$+8^<#H"1T[FO0#XZ_:8_;S,7AN'0C\.OAY>,O]H7Z020I
M+!GY@)),-+Q_"@ /<XK]$+7X@>'=5T35=8@F-S9Z7*\5RRQ$LK)UPO4]L8ZY
MXJK)\7?#]E:7D]\M_I26MO\ :I%U"QDA)BW!2ZAA\P!89QTR* N?E]^QY\ _
M&7PX_;7TAI_!_B.U\-Z=>WUO'JM[I<T<#1!)%C<R% OS#&#G!S7Z]5@7/C71
M[35=&TY[Q#>:N&:SB3YC*JKN+<=%QWI^E>,M*UGQ!JFBVEQYFH:9L^TQ[2-N
MX9&#T/OCI0#=S<HHHH$%(>12T4 >4?M!_!F/XO\ A&&W@2-=7L)UNK.5^,D$
M;D)[!AQ]<5YI_P *)\7_ //C#_X$)_C7U#BEKP,UR;#YQR?6&_=VLS.G3A2J
M2J16LM_D?+C? GQ>01]BA_\  A/\:SK[]GOQI<*0MA <^MRG^-?6E%>)#@[+
MZ;NG+[U_D;RFY*S/F'X0?LT:IHWQ!B\1^)K>%$L(S]DA659-TI_B..F!T^M?
M3<2E% -/HKZO!X*E@:?LJ6Q=2M4JQC&;NHJR] HHHKO,0HHHH *CE@CG&)$6
M0>C $5)10!'%!' "(T6,'G"# KS;XE>%=2UCQ9I-_;:=J5]:064\#G2]12TD
M5V>,C)9ER,*>GM7IM% 'B&G_  I\0IHMO:O%!%+;V++ )9A(H=;L31Q2,.6.
MT ,^.3SS6OXIT#Q-\0HT^TZ$-$%C:77EB2[BE>XGDA:-54H2%3G.6()XX%>L
M44 >/ZU\';Z[\$M#+J-_K&L_9(;6);B=$6V7?&T@3: ,X3[W)X%3ZU\.=9T?
M5[NX\.R7EV]UI;6(N=0OO-\AWE7+@,<X5=S8'7 %>LT4 >,W?PK\0Z+::A9:
M?=)J=GJ6EBQD$:);&*2,#RI.OS$@LI/LM/U3X7ZW'=7Z&6Y\1175G%%;W&H7
M*%[0K*C218X!5PN<@9XP>,5['10!Y-+\)W\)ZG8ZIH-M+J<]M<2RQP7$ZK]G
MA\I_+MXRQ&$WM^OH!3?#OPU\2^%M4\/ZK_:,.IW*2R+J4*PK$72=MTK;\_-L
/?! ] 0*];HH **** /_9

end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
