<SEC-DOCUMENT>0001437749-25-019599-index.html : 20250606
<SEC-HEADER>0001437749-25-019599.hdr.sgml : 20250606
<ACCEPTANCE-DATETIME>20250606060154
ACCESSION NUMBER:		0001437749-25-019599
CONFORMED SUBMISSION TYPE:	S-1MEF
PUBLIC DOCUMENT COUNT:		5
<REFERENCE-462B>333-287728
FILED AS OF DATE:		20250606
DATE AS OF CHANGE:		20250606
EFFECTIVENESS DATE:		20250606

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AYTU BIOPHARMA, INC
		CENTRAL INDEX KEY:			0001385818
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				470883144
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	FILING VALUES:
		FORM TYPE:		S-1MEF
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-287825
		FILM NUMBER:		251028753

	BUSINESS ADDRESS:	
		STREET 1:		7900 E. UNION AVENUE
		STREET 2:		SUITE 920
		CITY:			DENVER
		STATE:			CO
		ZIP:			80237
		BUSINESS PHONE:		(720) 437-6580

	MAIL ADDRESS:	
		STREET 1:		7900 E. UNION AVENUE
		STREET 2:		SUITE 920
		CITY:			DENVER
		STATE:			CO
		ZIP:			80237

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC
		DATE OF NAME CHANGE:	20150609

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC.
		DATE OF NAME CHANGE:	20150609

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Rosewind CORP
		DATE OF NAME CHANGE:	20070110
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-1MEF
<SEQUENCE>1
<FILENAME>aytu20250605_s1mef.htm
<DESCRIPTION>FORM S-1MEF
<TEXT>
Document 1 - file: aytu20250605_s1mef.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>ex_827551.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 2 - file: ex_827551.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>ex_827687.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 3 - file: ex_827687.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>4
<FILENAME>ex_827712.htm
<DESCRIPTION>EXHIBIT FILING FEES
<TEXT>
Document 4 - file: ex_827712.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>logo01.jpg
<TEXT>
Document 5 - file: logo01.jpg

</DOCUMENT>
</SEC-DOCUMENT>