<SEC-DOCUMENT>0000899243-18-009612.txt : 20180405
<SEC-HEADER>0000899243-18-009612.hdr.sgml : 20180405
<ACCEPTANCE-DATETIME>20180405202108
ACCESSION NUMBER:		0000899243-18-009612
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		6
CONFORMED PERIOD OF REPORT:	20180403
FILED AS OF DATE:		20180405
DATE AS OF CHANGE:		20180405

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Flint Jonathan A
		CENTRAL INDEX KEY:			0001295676

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36199
		FILM NUMBER:		18741751

	MAIL ADDRESS:	
		STREET 1:		1000 WINTER STREET
		STREET 2:		SUITE 3350
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			POLARIS VENTURE PARTNERS IV LP
		CENTRAL INDEX KEY:			0001157864
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36199
		FILM NUMBER:		18741748

	BUSINESS ADDRESS:	
		STREET 1:		1000 WINTER STREET
		STREET 2:		SUITE 3350
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			024511215
		BUSINESS PHONE:		7812900770

	MAIL ADDRESS:	
		STREET 1:		1000 WINTER STREET
		STREET 2:		SUITE 3350
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP
		CENTRAL INDEX KEY:			0001170720
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36199
		FILM NUMBER:		18741749

	BUSINESS ADDRESS:	
		STREET 1:		1000 WINTER STREET
		STREET 2:		SUITE 3350
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451-1215
		BUSINESS PHONE:		7812900770

	MAIL ADDRESS:	
		STREET 1:		1000 WINTER STREET
		STREET 2:		SUITE 3350
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Polaris Venture Management Co IV LLC
		CENTRAL INDEX KEY:			0001295438
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36199
		FILM NUMBER:		18741750

	BUSINESS ADDRESS:	
		STREET 1:		ONE MARINA PARK DRIVE
		STREET 2:		10TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		7812900770

	MAIL ADDRESS:	
		STREET 1:		ONE MARINA PARK DRIVE
		STREET 2:		10TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Polaris Venture Management Co. V, L.L.C.
		CENTRAL INDEX KEY:			0001439589
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36199
		FILM NUMBER:		18741747

	BUSINESS ADDRESS:	
		STREET 1:		ONE MARINA PARK DRIVE
		STREET 2:		10TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		781-290-0770

	MAIL ADDRESS:	
		STREET 1:		ONE MARINA PARK DRIVE
		STREET 2:		10TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Polaris Venture Partners V, L.P.
		CENTRAL INDEX KEY:			0001439590
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36199
		FILM NUMBER:		18741745

	BUSINESS ADDRESS:	
		STREET 1:		ONE MARINA PARK DRIVE
		STREET 2:		10TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		781-290-0770

	MAIL ADDRESS:	
		STREET 1:		ONE MARINA PARK DRIVE
		STREET 2:		10TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Polaris Venture Partners Founders' Fund V, L.P.
		CENTRAL INDEX KEY:			0001439588
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36199
		FILM NUMBER:		18741744

	BUSINESS ADDRESS:	
		STREET 1:		ONE MARINA PARK DRIVE
		STREET 2:		10TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		781-290-0770

	MAIL ADDRESS:	
		STREET 1:		ONE MARINA PARK DRIVE
		STREET 2:		10TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Polaris Venture Partners Entrepreneurs' Fund V, L.P.
		CENTRAL INDEX KEY:			0001439587
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36199
		FILM NUMBER:		18741746

	BUSINESS ADDRESS:	
		STREET 1:		ONE MARINA PARK DRIVE
		STREET 2:		10TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		781-290-0770

	MAIL ADDRESS:	
		STREET 1:		ONE MARINA PARK DRIVE
		STREET 2:		10TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Polaris Venture Partners Special Founders' Fund V, L.P.
		CENTRAL INDEX KEY:			0001439586
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36199
		FILM NUMBER:		18741743

	BUSINESS ADDRESS:	
		STREET 1:		ONE MARINA PARK DRIVE
		STREET 2:		10TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		781-290-0770

	MAIL ADDRESS:	
		STREET 1:		ONE MARINA PARK DRIVE
		STREET 2:		10TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			MCGUIRE TERRANCE
		CENTRAL INDEX KEY:			0001117003
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36199
		FILM NUMBER:		18741752

	MAIL ADDRESS:	
		STREET 1:		C/O POLARIS VENTURE PARTNERS LP
		STREET 2:		1000 WINTER STREET, SUITE 3350
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02154

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Pulmatrix, Inc.
		CENTRAL INDEX KEY:			0001574235
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				461821392
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		99 HAYDEN AVENUE
		STREET 2:		SUITE 390
		CITY:			LEXINGTON
		STATE:			MA
		ZIP:			02421
		BUSINESS PHONE:		(781) 357-2333

	MAIL ADDRESS:	
		STREET 1:		99 HAYDEN AVENUE
		STREET 2:		SUITE 390
		CITY:			LEXINGTON
		STATE:			MA
		ZIP:			02421

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Ruthigen, Inc.
		DATE OF NAME CHANGE:	20130411
</SEC-HEADER>
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            <rptOwnerStreet2></rptOwnerStreet2>
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            <rptOwnerState>MA</rptOwnerState>
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            <rptOwnerStreet2></rptOwnerStreet2>
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            <rptOwnerZipCode>02210</rptOwnerZipCode>
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            <rptOwnerName>Polaris Venture Partners V, L.P.</rptOwnerName>
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            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
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    <reportingOwner>
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            <rptOwnerStreet2></rptOwnerStreet2>
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            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02210</rptOwnerZipCode>
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    <reportingOwner>
        <reportingOwnerId>
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            <rptOwnerName>Polaris Venture Partners Special Founders' Fund V, L.P.</rptOwnerName>
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        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE MARINA PARK DRIVE, 10TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02210</rptOwnerZipCode>
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    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>345551</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
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                </transactionAcquiredDisposedCode>
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            <postTransactionAmounts>
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                    <value>1556676</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
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                    <value>See Footnotes</value>
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                    <footnoteId id="F4"/>
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            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
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                <transactionFormType>4</transactionFormType>
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                <value></value>
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            <transactionAmounts>
                <transactionShares>
                    <value>769989</value>
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                <transactionPricePerShare>
                    <footnoteId id="F7"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
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                <sharesOwnedFollowingTransaction>
                    <value>3468190</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F8"/>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
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        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
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                <value>2018-04-03</value>
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                <transactionFormType>4</transactionFormType>
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                <value></value>
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                <transactionShares>
                    <value>15007</value>
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                    <footnoteId id="F11"/>
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                    <value>A</value>
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                <sharesOwnedFollowingTransaction>
                    <value>67729</value>
                </sharesOwnedFollowingTransaction>
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            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
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                    <value>See Footnotes</value>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                    <footnoteId id="F12"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>5275</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F13"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>23875</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                    <footnoteId id="F14"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>7700</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F15"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>34587</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                    <footnoteId id="F16"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Series A Warrant (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.65</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>345551</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2018-04-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2018-10-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>345551</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>345551</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series B Warrant (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.75</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>345551</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2018-04-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2023-04-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>345551</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>345551</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series A Warrant (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.65</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>6478</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F5"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2018-04-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2018-10-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>6478</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>6478</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series B Warrant (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.75</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>6478</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F5"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2018-04-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2023-04-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>6478</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>6478</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series A Warrant (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.65</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>769989</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F7"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2018-04-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2018-10-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>769989</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>769989</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F8"/>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series B Warrant (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.75</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>769989</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F7"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2018-04-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2023-04-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>769989</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>769989</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F8"/>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series A Warrant (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.65</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>15007</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F11"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2018-04-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2018-10-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>15007</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>15007</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                    <footnoteId id="F12"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series B Warrant (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.75</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>15007</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F11"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2018-04-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2023-04-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>15007</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>15007</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                    <footnoteId id="F12"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series A Warrant (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.65</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>5275</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F13"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2018-04-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2018-10-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>5275</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>5275</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                    <footnoteId id="F14"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series B Warrant (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.75</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>5275</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F13"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2018-04-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2023-04-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>5275</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>5275</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                    <footnoteId id="F14"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series A Warrant (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.65</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>7700</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F15"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2018-04-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2018-10-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>7700</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>7700</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                    <footnoteId id="F16"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series B Warrant (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.75</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2018-04-03</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>7700</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F15"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2018-04-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2023-04-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>7700</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>7700</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                    <footnoteId id="F16"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The reported securities were included within 345,551 Units purchased by Polaris Venture Partners IV, L.P. (&quot;PVP IV&quot;) for $0.65 per Unit (each, a &quot;Unit&quot;).  Each Unit consisted of one share of common stock, one Series A Warrant to purchase one share of common stock at an exercise price of $0.65 per share, and one Series B Warrant to purchase one share of common stock at an exercise price of $0.75 per share.</footnote>
        <footnote id="F2">Securities held of record by PVP IV.</footnote>
        <footnote id="F3">Polaris Venture Management Co. IV, L.L.C. (&quot;PVM IV&quot;) is the general partner of PVP IV and Polaris Venture Partners Entrepreneurs' Fund IV, L.P. (&quot;PVPE IV&quot;). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM IV. PVM IV disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM IV is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM IV, may be deemed to have shared voting and dispositive power over the shares held by each of PVP IV and PVPE IV.</footnote>
        <footnote id="F4">Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.</footnote>
        <footnote id="F5">The reported securities were included within 6,478 Units purchased by PVPE IV.</footnote>
        <footnote id="F6">Securities held of record by PVPE IV.</footnote>
        <footnote id="F7">The reported securities were included within 769,989 Units purchased by Polaris Venture Partners V, L.P. (&quot;PVP V&quot;).</footnote>
        <footnote id="F8">Securities held of record by PVP V.</footnote>
        <footnote id="F9">Polaris Venture Management Co. V, LLC (&quot;PVM V&quot;) is the general partner of PVP V, Polaris Venture Partners Founders' Fund V, L.P. (&quot;PVPFF V&quot;), Polaris Venture Partners Special Founders' Fund V, L.P. (&quot;PVPSFF V&quot;) and Polaris Venture Partners Entrepreneurs' Fund V, L.P. (&quot;PVPEF V&quot;). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power over the shares held by each of PVP V, PVPFF V, PFPSFF V and PVPEF V.</footnote>
        <footnote id="F10">Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.</footnote>
        <footnote id="F11">The reported securities were included within 15,007 Units purchased by PVPEF V.</footnote>
        <footnote id="F12">Securities held of record by PVPEF V.</footnote>
        <footnote id="F13">The reported securities were included within 5,275 Units purchased by PVPFF V.</footnote>
        <footnote id="F14">Securities held of record by PVPFF V.</footnote>
        <footnote id="F15">The reported securities were included within 7,700 Units purchased by PVPSFF V.</footnote>
        <footnote id="F16">Securities held of record by PVPSFF V.</footnote>
    </footnotes>

    <remarks>Exhibit 24 -    Power of Attorney
		Polaris Venture Partners IV, L.P.
		Polaris Venture Partners Entrepreneurs' Fund IV, L.P.
		Polaris Venture Management Co. IV, L.L.C.
		Jonathan A. Flint
		Terrance G. McGuire</remarks>

    <ownerSignature>
        <signatureName>/s/ Max Eisenberg, Attorney-in-Fact for Terrance McGuire</signatureName>
        <signatureDate>2018-04-05</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Max Eisenberg, Attorney-in-Fact for Jonathan A. Flint</signatureName>
        <signatureDate>2018-04-05</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Max Eisenberg, Attorney-in-Fact for Polaris Venture Management Co. IV, L.L.C.</signatureName>
        <signatureDate>2018-04-05</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Max Eisenberg, Attorney-in-Fact for Polaris Venture Management Co. IV, L.L.C., general partner of Polaris Venture Partners Entrepreneurs' Fund IV, L.P.</signatureName>
        <signatureDate>2018-04-05</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Max Eisenberg, Attorney-in-Fact for Polaris Venture Management Co. IV, L.L.C., general partner of Polaris Venture Partners IV, L.P.</signatureName>
        <signatureDate>2018-04-05</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Max Eisenberg, Attorney-in-Fact for Polaris Venture Management Co. V, L.L.C.</signatureName>
        <signatureDate>2018-04-05</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Max Eisenberg, Attorney-in-Fact for Polaris Venture Management Co. V, L.L.C., general partner of Polaris Venture Partners Entrepreneurs' Fund V, L.P.</signatureName>
        <signatureDate>2018-04-05</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Max Eisenberg, Attorney-in-Fact for Polaris Venture Management Co. V, L.L.C., general partner of Polaris Venture Partners V, L.P.</signatureName>
        <signatureDate>2018-04-05</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Max Eisenberg, Attorney-in-Fact for Polaris Venture Management Co. V, L.L.C., general partner of Polaris Venture Partners Founders' Fund V, L.P.</signatureName>
        <signatureDate>2018-04-05</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Max Eisenberg, Attorney-in-Fact for Polaris Venture Management Co. V, L.L.C., general partner of Polaris Venture Partners Special Founders' Fund V, L.P.</signatureName>
        <signatureDate>2018-04-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
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<TYPE>EX-24.1
<SEQUENCE>2
<FILENAME>attachment1.htm
<DESCRIPTION>EX-24.1 DOCUMENT
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<PRE>
                                                                      EXHIBIT 24

                               POWER OF ATTORNEY

        The undersigned (the "Reporting Person") hereby constitutes and appoints
Max Benjamin Eisenberg, signing singly, with full power of substitution, as the
Reporting Person's true and lawful attorney in fact to:

        (1)    prepare, execute in the Reporting Person's name and on the
Reporting Person's behalf, and submit to the U.S. Securities and Exchange
Commission (the "SEC") a Form ID, including amendments thereto, and any other
documents necessary or appropriate to obtain codes and passwords enabling the
Reporting Person to make electronic filings with the SEC of Reports required by
Section 16(a) of the Securities Exchange Act of 1934 or any rule or regulation
of the SEC;

        (2)   prepare and file on behalf of such Reporting Person any and all
reports, notices, communications and other documents (including, but not limited
to, reports on Schedule 13D, Schedule 13G, Form 13-F, Form 3, Form 4 and Form 5)
that such Reporting Person may be required to file with the SEC pursuant to the
Securities Act of 1933, as amended (together with the implementing regulations
thereto, the "Act") and the Securities Exchange Act of 1934, as amended
(together with the implementing regulations thereto, the "Exchange Act")
(collectively, the "Reports") with respect to the Reporting Person's (a) status
as an officer or director of, or (b) ownership of, or transactions in, the
securities of, any entity whose securities are beneficially owned (directly or
indirectly) by the Reporting Person ("Portfolio Companies");

        (3)   do and perform any and all acts for and on behalf of the Reporting
Person which may be necessary or desirable to complete and execute any such
Reports, complete and execute any amendment or amendments thereto, and timely
file such form with the SEC and any stock exchange or similar authority; and

        (4)   take any other action of any type whatsoever in connection with
the foregoing which, in the opinion of such attorney in fact, may be of benefit
to, in the best interest of, or legally required by, the Reporting Person, it
being understood that the documents executed by such attorney in fact on behalf
of the Reporting Person pursuant to this Power of Attorney shall be in such form
and shall contain such terms and conditions as such attorney in fact may approve
in such attorney in fact's discretion.

        The Reporting Person hereby grants to such attorney in fact full power
and authority to do and perform any and every act and thing whatsoever
requisite, necessary, or proper to be done in the exercise of any of the rights
and powers herein granted, as fully to all intents and purposes as the Reporting
Person might or could do if personally present, with full power of substitution
or revocation, hereby ratifying and confirming all that such attorney in fact,
or such attorney in fact's substitute or substitutes, shall lawfully do or cause
to be done by virtue of this power of attorney and the rights and powers herein
granted. The Reporting Person acknowledges that the foregoing attorney in fact,
in serving in such capacity at the request of the Reporting Person, is not
assuming any of the Reporting Person's responsibilities to comply with Section
16 of the Securities Exchange Act of 1934.

        This Power of Attorney with respect to the Reporting Person shall remain
in full force and effect until such Reporting Person is no longer required to
file any Reports with respect to the Reporting Person's ownership of, or
transactions in, the securities of Portfolio Companies, unless earlier revoked
in a signed writing delivered to the foregoing attorney in fact.

        IN WITNESS WHEREOF, the undersigned have caused this Power of Attorney
to be executed as of this 26th day of September, 2016.




                                  Polaris Venture Partners IV, L.P.

                                  By: Polaris Venture Management Co. IV, L.L.C.,
                                  its General Partner


                                  By:     /s/ Terrance McGuire
                                         ---------------------------------------
                                  Name:   Terrance McGuire
                                         ---------------------------------------
                                  Title:  Managing Member
                                         ---------------------------------------

</PRE>
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<DESCRIPTION>EX-24.2 DOCUMENT
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<PRE>
                                                                      EXHIBIT 24

                               POWER OF ATTORNEY


        The undersigned (the "Reporting Person") hereby constitutes and appoints
Max Benjamin Eisenberg, signing singly, with full power of substitution, as the
Reporting Person's true and lawful attorney in fact to:

        (1)    prepare, execute in the Reporting Person's name and on the
Reporting Person's behalf, and submit to the U.S. Securities and Exchange
Commission (the "SEC") a Form ID, including amendments thereto, and any other
documents necessary or appropriate to obtain codes and passwords enabling the
Reporting Person to make electronic filings with the SEC of Reports required by
Section 16(a) of the Securities Exchange Act of 1934 or any rule or regulation
of the SEC;

        (2)   prepare and file on behalf of such Reporting Person any and all
reports, notices, communications and other documents (including, but not limited
to, reports on Schedule 13D, Schedule 13G, Form 13-F, Form 3, Form 4 and Form 5)
that such Reporting Person may be required to file with the SEC pursuant to the
Securities Act of 1933, as amended (together with the implementing regulations
thereto, the "Act") and the Securities Exchange Act of 1934, as amended
(together with the implementing regulations thereto, the "Exchange Act")
(collectively, the "Reports") with respect to the Reporting Person's (a) status
as an officer or director of, or (b) ownership of, or transactions in, the
securities of, any entity whose securities are beneficially owned (directly or
indirectly) by the Reporting Person ("Portfolio Companies");

        (3)   do and perform any and all acts for and on behalf of the Reporting
Person which may be necessary or desirable to complete and execute any such
Reports, complete and execute any amendment or amendments thereto, and timely
file such form with the SEC and any stock exchange or similar authority; and

        (4)   take any other action of any type whatsoever in connection with
the foregoing which, in the opinion of such attorney in fact, may be of benefit
to, in the best interest of, or legally required by, the Reporting Person, it
being understood that the documents executed by such attorney in fact on behalf
of the Reporting Person pursuant to this Power of Attorney shall be in such form
and shall contain such terms and conditions as such attorney in fact may approve
in such attorney in fact's discretion.

        The Reporting Person hereby grants to such attorney in fact full power
and authority to do and perform any and every act and thing whatsoever
requisite, necessary, or proper to be done in the exercise of any of the rights
and powers herein granted, as fully to all intents and purposes as the Reporting
Person might or could do if personally present, with full power of substitution
or revocation, hereby ratifying and confirming all that such attorney in fact,
or such attorney in fact's substitute or substitutes, shall lawfully do or cause
to be done by virtue of this power of attorney and the rights and powers herein
granted. The Reporting Person acknowledges that the foregoing attorney in fact,
in serving in such capacity at the request of the Reporting Person, is not
assuming any of the Reporting Person's responsibilities to comply with Section
16 of the Securities Exchange Act of 1934.

        This Power of Attorney with respect to the Reporting Person shall remain
in full force and effect until such Reporting Person is no longer required to
file any Reports with respect to the Reporting Person's ownership of, or
transactions in, the securities of Portfolio Companies, unless earlier revoked
in a signed writing delivered to the foregoing attorney in fact.

        IN WITNESS WHEREOF, the undersigned have caused this Power of Attorney
to be executed as of this 26th day of September, 2016.




                                  Polaris Venture Partners Entrepreneurs'
                                  Fund IV, L.P

                                  By: Polaris Venture Management Co. IV, L.L.C.,
                                  its General Partner


                                  By:     /s/ Terrance McGuire
                                         ---------------------------------------
                                  Name:   Terrance McGuire
                                         ---------------------------------------
                                  Title:  Managing Member
                                         ---------------------------------------

</PRE>
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<FILENAME>attachment3.htm
<DESCRIPTION>EX-24.3 DOCUMENT
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<PRE>
                                                                      EXHIBIT 24

                               POWER OF ATTORNEY

        The undersigned (the "Reporting Person") hereby constitutes and appoints
Max Benjamin Eisenberg, signing singly, with full power of substitution, as the
Reporting Person's true and lawful attorney in fact to:

        (1)    prepare, execute in the Reporting Person's name and on the
Reporting Person's behalf, and submit to the U.S. Securities and Exchange
Commission (the "SEC") a Form ID, including amendments thereto, and any other
documents necessary or appropriate to obtain codes and passwords enabling the
Reporting Person to make electronic filings with the SEC of Reports required by
Section 16(a) of the Securities Exchange Act of 1934 or any rule or regulation
of the SEC;

        (2)   prepare and file on behalf of such Reporting Person any and all
reports, notices, communications and other documents (including, but not limited
to, reports on Schedule 13D, Schedule 13G, Form 13-F, Form 3, Form 4 and Form 5)
that such Reporting Person may be required to file with the SEC pursuant to the
Securities Act of 1933, as amended (together with the implementing regulations
thereto, the "Act") and the Securities Exchange Act of 1934, as amended
(together with the implementing regulations thereto, the "Exchange Act")
(collectively, the "Reports") with respect to the Reporting Person's (a) status
as an officer or director of, or (b) ownership of, or transactions in, the
securities of, any entity whose securities are beneficially owned (directly or
indirectly) by the Reporting Person ("Portfolio Companies");

        (3)   do and perform any and all acts for and on behalf of the Reporting
Person which may be necessary or desirable to complete and execute any such
Reports, complete and execute any amendment or amendments thereto, and timely
file such form with the SEC and any stock exchange or similar authority; and

        (4)   take any other action of any type whatsoever in connection with
the foregoing which, in the opinion of such attorney in fact, may be of benefit
to, in the best interest of, or legally required by, the Reporting Person, it
being understood that the documents executed by such attorney in fact on behalf
of the Reporting Person pursuant to this Power of Attorney shall be in such form
and shall contain such terms and conditions as such attorney in fact may approve
in such attorney in fact's discretion.

        The Reporting Person hereby grants to such attorney in fact full power
and authority to do and perform any and every act and thing whatsoever
requisite, necessary, or proper to be done in the exercise of any of the rights
and powers herein granted, as fully to all intents and purposes as the Reporting
Person might or could do if personally present, with full power of substitution
or revocation, hereby ratifying and confirming all that such attorney in fact,
or such attorney in fact's substitute or substitutes, shall lawfully do or cause
to be done by virtue of this power of attorney and the rights and powers herein
granted. The Reporting Person acknowledges that the foregoing attorney in fact,
in serving in such capacity at the request of the Reporting Person, is not
assuming any of the Reporting Person's responsibilities to comply with Section
16 of the Securities Exchange Act of 1934.

        This Power of Attorney with respect to the Reporting Person shall remain
in full force and effect until such Reporting Person is no longer required to
file any Reports with respect to the Reporting Person's ownership of, or
transactions in, the securities of Portfolio Companies, unless earlier revoked
in a signed writing delivered to the foregoing attorney in fact.

        IN WITNESS WHEREOF, the undersigned have caused this Power of Attorney
to be executed as of this 26th day of September, 2016.




                                  Polaris Venture Management Co. IV, L.L.C.


                                  By:     /s/ Terrance McGuire
                                         ---------------------------------------
                                  Name:   Terrance McGuire
                                         ---------------------------------------
                                  Title:  Managing Member
                                         ---------------------------------------

</PRE>
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<SEQUENCE>5
<FILENAME>attachment4.htm
<DESCRIPTION>EX-24.4 DOCUMENT
<TEXT>
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</HEAD>
<BODY>
<PRE>
                                                                      EXHIBIT 24

                               POWER OF ATTORNEY

        The undersigned (the "Reporting Person") hereby constitutes and appoints
Max Benjamin Eisenberg, signing singly, with full power of substitution, as the
Reporting Person's true and lawful attorney in fact to:

        (1)    prepare, execute in the Reporting Person's name and on the
Reporting Person's behalf, and submit to the U.S. Securities and Exchange
Commission (the "SEC") a Form ID, including amendments thereto, and any other
documents necessary or appropriate to obtain codes and passwords enabling the
Reporting Person to make electronic filings with the SEC of Reports required by
Section 16(a) of the Securities Exchange Act of 1934 or any rule or regulation
of the SEC;

        (2)   prepare and file on behalf of such Reporting Person any and all
reports, notices, communications and other documents (including, but not limited
to, reports on Schedule 13D, Schedule 13G, Form 13-F, Form 3, Form 4 and Form 5)
that such Reporting Person may be required to file with the SEC pursuant to the
Securities Act of 1933, as amended (together with the implementing regulations
thereto, the "Act") and the Securities Exchange Act of 1934, as amended
(together with the implementing regulations thereto, the "Exchange Act")
(collectively, the "Reports") with respect to the Reporting Person's (a) status
as an officer or director of, or (b) ownership of, or transactions in, the
securities of, any entity whose securities are beneficially owned (directly or
indirectly) by the Reporting Person ("Portfolio Companies");

        (3)   do and perform any and all acts for and on behalf of the Reporting
Person which may be necessary or desirable to complete and execute any such
Reports, complete and execute any amendment or amendments thereto, and timely
file such form with the SEC and any stock exchange or similar authority; and

        (4)   take any other action of any type whatsoever in connection with
the foregoing which, in the opinion of such attorney in fact, may be of benefit
to, in the best interest of, or legally required by, the Reporting Person, it
being understood that the documents executed by such attorney in fact on behalf
of the Reporting Person pursuant to this Power of Attorney shall be in such form
and shall contain such terms and conditions as such attorney in fact may approve
in such attorney in fact's discretion.

        The Reporting Person hereby grants to such attorney in fact full power
and authority to do and perform any and every act and thing whatsoever
requisite, necessary, or proper to be done in the exercise of any of the rights
and powers herein granted, as fully to all intents and purposes as the Reporting
Person might or could do if personally present, with full power of substitution
or revocation, hereby ratifying and confirming all that such attorney in fact,
or such attorney in fact's substitute or substitutes, shall lawfully do or cause
to be done by virtue of this power of attorney and the rights and powers herein
granted. The Reporting Person acknowledges that the foregoing attorney in fact,
in serving in such capacity at the request of the Reporting Person, is not
assuming any of the Reporting Person's responsibilities to comply with Section
16 of the Securities Exchange Act of 1934.

        This Power of Attorney with respect to the Reporting Person shall remain
in full force and effect until such Reporting Person is no longer required to
file any Reports with respect to the Reporting Person's ownership of, or
transactions in, the securities of Portfolio Companies, unless earlier revoked
in a signed writing delivered to the foregoing attorney in fact.

        IN WITNESS WHEREOF, the undersigned have caused this Power of Attorney
to be executed as of this 13th day of September, 2016.




                                  /s/ Jonathan A. Flint
                                  ------------------------
                                  Jonathan A. Flint

</PRE>
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<TYPE>EX-24.5
<SEQUENCE>6
<FILENAME>attachment5.htm
<DESCRIPTION>EX-24.5 DOCUMENT
<TEXT>
<HTML>
<HEAD>
</HEAD>
<BODY>
<PRE>
                                                                      EXHIBIT 24

                               POWER OF ATTORNEY

        The undersigned (the "Reporting Person") hereby constitutes and appoints
Max Benjamin Eisenberg, signing singly, with full power of substitution, as the
Reporting Person's true and lawful attorney in fact to:

        (1)    prepare, execute in the Reporting Person's name and on the
Reporting Person's behalf, and submit to the U.S. Securities and Exchange
Commission (the "SEC") a Form ID, including amendments thereto, and any other
documents necessary or appropriate to obtain codes and passwords enabling the
Reporting Person to make electronic filings with the SEC of Reports required by
Section 16(a) of the Securities Exchange Act of 1934 or any rule or regulation
of the SEC;

        (2)   prepare and file on behalf of such Reporting Person any and all
reports, notices, communications and other documents (including, but not limited
to, reports on Schedule 13D, Schedule 13G, Form 13-F, Form 3, Form 4 and Form 5)
that such Reporting Person may be required to file with the SEC pursuant to the
Securities Act of 1933, as amended (together with the implementing regulations
thereto, the "Act") and the Securities Exchange Act of 1934, as amended
(together with the implementing regulations thereto, the "Exchange Act")
(collectively, the "Reports") with respect to the Reporting Person's (a) status
as an officer or director of, or (b) ownership of, or transactions in, the
securities of, any entity whose securities are beneficially owned (directly or
indirectly) by the Reporting Person ("Portfolio Companies");

        (3)   do and perform any and all acts for and on behalf of the Reporting
Person which may be necessary or desirable to complete and execute any such
Reports, complete and execute any amendment or amendments thereto, and timely
file such form with the SEC and any stock exchange or similar authority; and

        (4)   take any other action of any type whatsoever in connection with
the foregoing which, in the opinion of such attorney in fact, may be of benefit
to, in the best interest of, or legally required by, the Reporting Person, it
being understood that the documents executed by such attorney in fact on behalf
of the Reporting Person pursuant to this Power of Attorney shall be in such form
and shall contain such terms and conditions as such attorney in fact may approve
in such attorney in fact's discretion.

        The Reporting Person hereby grants to such attorney in fact full power
and authority to do and perform any and every act and thing whatsoever
requisite, necessary, or proper to be done in the exercise of any of the rights
and powers herein granted, as fully to all intents and purposes as the Reporting
Person might or could do if personally present, with full power of substitution
or revocation, hereby ratifying and confirming all that such attorney in fact,
or such attorney in fact's substitute or substitutes, shall lawfully do or cause
to be done by virtue of this power of attorney and the rights and powers herein
granted. The Reporting Person acknowledges that the foregoing attorney in fact,
in serving in such capacity at the request of the Reporting Person, is not
assuming any of the Reporting Person's responsibilities to comply with Section
16 of the Securities Exchange Act of 1934.

        This Power of Attorney with respect to the Reporting Person shall remain
in full force and effect until such Reporting Person is no longer required to
file any Reports with respect to the Reporting Person's ownership of, or
transactions in, the securities of Portfolio Companies, unless earlier revoked
in a signed writing delivered to the foregoing attorney in fact.

        IN WITNESS WHEREOF, the undersigned have caused this Power of Attorney
to be executed as of this 9th day of March, 2017.




                                  /s/ Terrance G. McGuire
                                  -----------------------
                                  Terrance G. McGuire
</PRE>
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