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Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2019

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Summary of Stock Option Activity

The following table summarizes stock option activity for the nine months ended September 30, 2019:

		Number of Options				Weighted- Average Exercise Price				Weighted- Average Remaining Contractual Term ( Years)				Aggregate Intrinsic Value
Outstanding — January 1, 2019			972,569			$	23.85				0			$	0
Granted			651,600			$	1.06				0				0
Exercised			0			$	0				0				0
Forfeited or expired			(535,493	)		$	23.77				0				0
Outstanding — September 30, 2019			1,088,676			$	10.25				8.86			$	0
Exercisable — September 30, 2019			355,845			$	26.24				7.77			$	0
Vested and expected to vest — September 30, 2019			1,082,710			$	10.28				8.86			$	0

Calculation of Fair Value Assumptions Using Black Scholes Option Model

The estimated fair values of employee stock options granted during the three and nine months ended September 30, 2019 and 2018, were determined on the date of grant using the Black-Scholes option-pricing model with the following assumptions:

		Three Months Ended September 30,								Nine Months Ended September 30,
		2019				2018				2019				2018
Expected option life (years)			0				6.05				6.02				5.58
Risk-free interest rate			0				2.79	%			2.22	%			2.77	%
Expected volatility			0				78.91	%			74.14	%			79.67	%
Expected dividend yield			0				0	%			0	%			0	%

Stock-Based Compensation Expense

The following table presents total stock-based compensation expense for the three and nine months ended September 30, 2019 and 2018:

		Three Months Ended September 30,								Nine months Ended September 30,
		2019				2018				2019				2018
Research and development		$	14			$	244			$	81			$	760
General and administrative			171				416			$	1,654			$	1,598
Total stock based compensation expense		$	185			$	660			$	1,735			$	2,358

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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