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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock [Member]
Additional Paid-in Capital [Member]
Accumulated deficit [Member]
Beginning balance at Dec. 31, 2017 $ 10,137   $ 184,139 $ (174,002)
Beginning balance, shares at Dec. 31, 2017   2,104,750    
Issuance of common stock, net of issuance costs 1,847   1,847  
Issuance of common stock, net of issuance costs, shares   123,266    
Stock-based compensation 765   765  
Net loss (5,221)     (5,221)
Ending balance at Mar. 31, 2018 7,528   186,751 (179,223)
Ending balance, shares at Mar. 31, 2018   2,228,016    
Beginning balance at Dec. 31, 2017 10,137   184,139 (174,002)
Beginning balance, shares at Dec. 31, 2017   2,104,750    
Net loss (16,225)      
Ending balance at Sep. 30, 2018 12,634   202,861 (190,227)
Ending balance, shares at Sep. 30, 2018   4,692,723    
Beginning balance at Mar. 31, 2018 7,528   186,751 (179,223)
Beginning balance, shares at Mar. 31, 2018   2,228,016    
Issuance of common stock, net of issuance costs 14,449   14,447  
Issuance of common stock, net of issuance costs, shares   1,681,000    
Exercise of pre-funded warrants 76   78  
Exercise of pre-funded warrants, shares   783,707    
Stock-based compensation 933   933  
Net loss (6,188)     (6,188)
Ending balance at Jun. 30, 2018 16,798   202,209 (185,411)
Ending balance, shares at Jun. 30, 2018   4,692,723    
Shares issuance costs (8)   (8)  
Stock-based compensation 660   660  
Net loss (4,816)     (4,816)
Ending balance at Sep. 30, 2018 12,634   202,861 (190,227)
Ending balance, shares at Sep. 30, 2018   4,692,723    
Beginning balance at Dec. 31, 2018 11,844   206,409 (194,565)
Beginning balance, shares at Dec. 31, 2018   4,932,723    
Adjustment for reverse stock split, shares   2,717    
Issuance of common stock, net of issuance costs 2,979 $ 1 2,978  
Issuance of common stock, net of issuance costs, shares   2,394,955    
Exercise of pre-funded warrants 70   70  
Exercise of pre-funded warrants, shares   697,500    
Stock-based compensation 459   459  
Net loss (5,156)     (5,156)
Ending balance at Mar. 31, 2019 10,196 $ 1 209,916 (199,721)
Ending balance, shares at Mar. 31, 2019   8,027,895    
Beginning balance at Dec. 31, 2018 11,844   206,409 (194,565)
Beginning balance, shares at Dec. 31, 2018   4,932,723    
Net loss (16,555)      
Ending balance at Sep. 30, 2019 14,726 $ 2 225,844 (211,120)
Ending balance, shares at Sep. 30, 2019   19,994,560    
Beginning balance at Mar. 31, 2019 10,196 $ 1 209,916 (199,721)
Beginning balance, shares at Mar. 31, 2019   8,027,895    
Issuance of common stock, net of issuance costs 14,566   14,566  
Issuance of common stock, net of issuance costs, shares   3,319,553    
Exercise of pre-funded warrants 83 $ 1 82  
Exercise of pre-funded warrants, shares   8,277,112    
Stock-based compensation 1,091   1,091  
Net loss (7,844)     (7,844)
Ending balance at Jun. 30, 2019 $ 18,092 $ 2 225,655 (207,565)
Ending balance, shares at Jun. 30, 2019   19,624,560    
Issuance of common stock, net of issuance costs, shares 370,000      
Exercise of pre-funded warrants $ 4   4  
Exercise of pre-funded warrants, shares   370,000    
Stock-based compensation 185   185  
Net loss (3,555)     (3,555)
Ending balance at Sep. 30, 2019 $ 14,726 $ 2 $ 225,844 $ (211,120)
Ending balance, shares at Sep. 30, 2019   19,994,560