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Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2022

Share-Based Payment Arrangement [Abstract]

Summary of Stock Option Activity

The following table summarizes stock option activity for the nine months ended September 30, 2022:

Summary of Stock Option Activity  

		Number of Options				Weighted-Average Exercise Price				Weighted- Average Remaining Contractual Term (Years)				Aggregate Intrinsic Value
Outstanding — January 1, 2022			196,006			$	52.72				8.12			$	-
Granted			123,357				6.45
Forfeited or expired			(11,445	)			200.12
Outstanding — September 30, 2022			307,918			$	28.70				8.22			$	-
Exercisable — September 30, 2022			136,308			$	46.42				7.42			$	-

Schedule of Calculation of Fair Value Assumptions

Schedule of Calculation of Fair Value Assumptions 

		Nine Months Ended September 30,
		2022				2021
Expected option life (years)			6.03				5.98
Risk-free interest rate			2.03	%			0.62	%
Expected volatility			113.28	%			104.96	%
Expected dividend yield			-	%			-	%

Schedule of Stock-based Compensation Expenses

The following table presents total stock-based compensation expense for the three and nine months ended September 30, 2022 and 2021, respectively (dollars in thousands):

Schedule of Stock-based Compensation Expenses 

		2022				2021				2022				2021
		Three Months Ended September 30,								Nine Months Ended September 30,
		2022				2021				2022				2021
Research and development		$	65			$	53			$	189			$	164
General and administrative			212				231				646				747
Total stock-based compensation expense		$	277			$	284			$	835			$	911

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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