<SEC-DOCUMENT>0001580111-26-000006.txt : 20260507
<SEC-HEADER>0001580111-26-000006.hdr.sgml : 20260507
<ACCEPTANCE-DATETIME>20260507202328
ACCESSION NUMBER:		0001580111-26-000006
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20260505
FILED AS OF DATE:		20260507
DATE AS OF CHANGE:		20260507

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Holles Natalie C.
		CENTRAL INDEX KEY:			0001580111
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39503
		FILM NUMBER:		26955623

	MAIL ADDRESS:	
		STREET 1:		C/O HYPERION THERAPEUTICS, INC.
		STREET 2:		2000 SIERRA POINT PARKWAY, SUITE 400
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LeonaBio, Inc.
		CENTRAL INDEX KEY:			0001620463
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				453368487
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		18706 NORTH CREEK PARKWAY, SUITE 104
		CITY:			BOTHELL
		STATE:			WA
		ZIP:			98011
		BUSINESS PHONE:		(425) 620-8501

	MAIL ADDRESS:	
		STREET 1:		18706 NORTH CREEK PARKWAY, SUITE 104
		CITY:			BOTHELL
		STATE:			WA
		ZIP:			98011

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Athira Pharma, Inc.
		DATE OF NAME CHANGE:	20190916

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	M3 Biotechnology, Inc.
		DATE OF NAME CHANGE:	20140924
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form3-05082026_120521.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0607</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2026-05-05</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001620463</issuerCik>
        <issuerName>LeonaBio, Inc.</issuerName>
        <issuerTradingSymbol>LONA</issuerTradingSymbol>
        <issuerForeignTradingSymbol></issuerForeignTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001580111</rptOwnerCik>
            <rptOwnerName>Holles Natalie C.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerNonUSAddressFlag>false</rptOwnerNonUSAddressFlag>
            <rptOwnerStreet1>C/O LEONABIO, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>18706 NORTH CREEK PARKWAY, SUITE 104</rptOwnerStreet2>
            <rptOwnerCity>BOTHELL</rptOwnerCity>
            <rptOwnerState>WA</rptOwnerState>
            <rptOwnerZipCode>98011</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <ownerSignature>
        <signatureName>/s/ Mark Worthington, Attorney-in-Fact for Natalie C. Holles</signatureName>
        <signatureDate>2026-05-07</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>ex24-05082026_120523.htm
<TEXT>
<!DOCTYPE html PUBLIC "-//IETF//DTD HTML//EN">
<html><head><title>ex24-05082026_120523.htm</title></head><body style="margin-top:0;font-family:Times New Roman; font-size:10pt; color:#000000">
<p style="margin:0px"><br></p>
<p style="margin:0px" align="center"><br></p>
<p style="margin:0px" align="center"><b>POWER OF ATTORNEY</b></p>
<p style="margin:0px" align="justify"><br></p>
<p style="margin:0px; text-indent:48px" align="justify">The undersigned hereby constitutes and appoints Mark Worthington, Robert Renninger, Vieng Keophilavanh, Barbara Mery, and each of the responsible attorneys and paralegals of Wilson Sonsini Goodrich &amp; Rosati, Professional Corporation, the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s true and lawful attorney-in-fact to:</p>
<p style="margin:0px" align="justify"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; text-indent:48px; width:72px; float:left">1.</p>
<p style="margin:0px; padding-left:72px; text-indent:-2px" align="justify">execute for and on behalf of the undersigned, in the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s capacity as an officer and/or director of LeonaBio, Inc. (the <font style="font-family:Arial Unicode MS,Times New Roman">&ldquo;</font>Company<font style="font-family:Arial Unicode MS,Times New Roman">&rdquo;</font>), Form ID, Update Passphrase Acknowledgment, Schedules 13D and 13G, Forms 3, 4 and 5 and amendments thereto in accordance with Section 16(a) of the Securities Exchange Act of 1934, as amended (the <font style="font-family:Arial Unicode MS,Times New Roman">&ldquo;</font>Exchange Act<font style="font-family:Arial Unicode MS,Times New Roman">&rdquo;</font>), and the rules thereunder, and Form 144 and amendments thereto in accordance with Rule 144 promulgated under the Securities Act of 1933, as amended (the <font style="font-family:Arial Unicode MS,Times New Roman">&ldquo;</font>Securities Act<font style="font-family:Arial Unicode MS,Times New Roman">&rdquo;</font>);</p>
<p style="margin:0px; clear:left" align="justify"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; text-indent:48px; width:72px; float:left">2.</p>
<p style="margin:0px; padding-left:72px; text-indent:-2px" align="justify">do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such, Form ID, Update Passphrase Acknowledgment, Form 144, Schedules 13D and 13G, and Forms 3, 4 and 5 and amendments thereto and timely file such form with the United States Securities and Exchange Commission and any stock exchange or similar authority. </p>
<p style="margin:0px; clear:left" align="justify"><br></p>
<p style="line-height:13.25pt; margin-top:0px; margin-bottom:-2px; text-indent:48px; width:72px; float:left">3.</p>
<p style="line-height:13.25pt; margin:0px; padding-left:72px; text-indent:-2px" align="justify">serve as the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s <font style="font-family:Arial Unicode MS,Times New Roman">&ldquo;</font>account administrator<font style="font-family:Arial Unicode MS,Times New Roman">&rdquo;</font> pursuant to the Electronic Data Gathering, Analysis, and Retrieval system (<font style="font-family:Arial Unicode MS,Times New Roman">&ldquo;</font><b>EDGAR</b><font style="font-family:Arial Unicode MS,Times New Roman">&rdquo;</font>) of the U.S. Securities and Exchange Commission, which role includes (i) appointing, removing, and replacing account administrators, technical administrators, account users, and delegated entities; (ii) maintaining the security of the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s EDGAR account, including modification of access codes; (iii) maintaining, modifying, and certifying the accuracy of information on the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s EDGAR account dashboard; and (iv) taking any other actions contemplated by Rule 10 of Regulation S-T.</p>
<p style="line-height:13.25pt; margin:0px; clear:left" align="justify"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; text-indent:48px; width:72px; float:left">4.</p>
<p style="margin:0px; padding-left:72px; text-indent:-2px" align="justify">take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be necessary or desirable in connection with the foregoing authority, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve.</p>
<p style="line-height:13.1pt; margin:0px; clear:left" align="justify"><br></p>
<p style="line-height:13.1pt; margin:0px; padding-left:24px" align="justify">The undersigned hereby ratifies and confirms all that said attorneys-in-fact, agents, and account administrators shall do or cause to be done by virtue hereof. The undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned, are not assuming (i) any of the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s responsibilities to comply with the Securities Exchange Act of 1934 (as amended) (the <font style="font-family:Arial Unicode MS,Times New Roman">&ldquo;</font><b>Exchange Act</b><font style="font-family:Arial Unicode MS,Times New Roman">&rdquo;</font>), (ii) any liability of the undersigned for failure to comply with such requirements, or (iii) any obligation or liability of the undersigned for profit disgorgement under Section 16(b) of the Exchange Act.</p>
<p style="line-height:13.1pt; margin:0px" align="justify"><br></p>
<p style="margin:0px; text-indent:24px">This Limited Power of Attorney shall remain in full force and effect until the earlier to occur of the following: (i) the date on which the undersigned is no longer required to file Form ID, Update Passphrase Acknowledgment, Form 144, Schedules 13D and 13G, Forms 3, 4 and 5 and amendments thereto with respect to the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s holdings of and transactions in securities issued by LeonaBio, Inc.; (ii) the date on which the applicable account administrator is removed as an account administrator on the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s EDGAR account; or (iii) the date on which this Limited Power of Attorney is revoked by the undersigned in a writing delivered to the applicable foregoing attorney-in-fact. </p>
<p style="margin:0px" align="justify"><br></p>
<p style="margin:0px; text-indent:48px" align="justify">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of May 6, 2026.</p>
<p style="margin:0px"><br></p>
<table style="margin-top:0px; font-size:10pt" cellpadding="0" cellspacing="0" width="100%" align="center"><tr style="font-size:0"><td width="151.133"></td><td width="43.4"></td><td width="138.8"></td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="151.133"><p style="margin-top:8px; margin-bottom:0px"><br></p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="43.4"><p style="margin-top:8px; margin-bottom:0px">Signature:</p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px; border-bottom:1px solid #000000" valign="top" width="138.8"><p style="margin-top:8px; margin-bottom:0px">/s/ Natalie C. Holles</p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="151.133"><p style="margin:0px"><br></p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="43.4"><p style="margin:0px"><br></p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="138.8"><p style="margin:0px"><br></p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="151.133"><p style="margin:0px"><br></p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="43.4"><p style="margin:0px">Name:</p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px; border-bottom:1px solid #000000" valign="top" width="138.8"><p style="margin:0px">Natalie C. Holles</p>
</td></tr></table><p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
</body></html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
