Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report on Form 10-Q of iBio, Inc. (the “Company”) for the quarterly period ended September 30, 2024 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Martin Brenner, Chief Executive Officer and Chief Scientific Officer (Principal Executive Officer) of the Company, certify pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

| 1. | The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

| 2. | The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company. ​

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​ ​ ​ ​ 1. The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and ​ ​ ​ ​ ​ ​ ​ ​ 2. The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company. ​ ​ ​ ​ ​ |  |
Date: | November 12, 2024 | /s/ Martin Brenner
|  | Martin Brenner
|  | Chief Executive Officer and Chief Scientific Officer
|  | (Principal Executive Officer)

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