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Note 6 - Stockholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2012
Allocation of Net Proceeds from Preferred Stock Financing [Table Text Block] |
Net proceeds after transaction costs |  | $ | 1,999,032 |
Less: Fair value of warrants (recorded to Additional Paid-in Capital) |  |  | (1,127,418 | )
Beneficial conversion feature (recorded to Additional Paid-in Capital) |  |  | (762,667 | )
Net proceeds allocated to preferred stock |  |  | 108,947 |
Accretion of beneficial conversion feature (deemed dividend) |  |  | 762,667 |
Initial carrying value of preferred stock |  |  | 871,614 |
Conversions to common stock |  |  | (559,418 | )
Carrying value of preferred stock at December 31, 2012 |  | $ | 312,196 |
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] |
|  | Number of Shares |  |  | Weighted- Average Exercise Price |  |  | Weighted- Average Remaining Contractual Term (yrs) |  |  | Aggregate Intrinsic Value |
Outstanding at December 31, 2011 |  |  | 928,242 |  |  | $ | 5.43 |  |  |  |  |  |  |
Granted |  |  | 238,500 |  |  |  | 0.70 |  |  |  |  |  |  |
Exercised |  |  | - |  |  |  | - |  |  |  |  |  |  |
Forfeited or expired |  |  | (97,601 | ) |  |  | 4.02 |  |  |  |  |  |  |
Outstanding at December 31, 2012 |  |  | 1,069,141 |  |  | $ | 4.50 |  |  |  | 6.2 |  |  | $ | -0- |
Exercisable at December 31, 2012 |  |  | 698,995 |  |  | $ | 6.38 |  |  |  | 4.6 |  |  | $ | -0- |
Additional Information Concerning Stock Options [Table Text Block] |
|  | 2012 |  |  | 2011 |  |  | 2010 |
Weighted average fair value of options granted during the period |  | $ | 0.59 |  |  | $ | 0.79 |  |  | $ | 2.95 |
Intrinsic value of options exercised during the period |  |  | - |  |  |  | - |  |  |  | - |
Total fair value of options vested during the period |  |  | 319,920 |  |  |  | 540,339 |  |  |  | 499,557 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | 2012 |  |  | 2011 |  |  | 2010 |
Weighted average risk-free interest rates |  |  | 1.1 | % |  |  | 1.4 | % |  |  | 2.6 | %
Expected dividend yield |  |  | 0.0 | % |  |  | 0.0 | % |  |  | 0.0 | %
Expected life of option (yrs) |  | 6.7 |  |  | 7 |  |  | 6.7 |
Expected volatility |  |  | 105.2 | % |  |  | 111.2 | % |  |  | 112.9 | %
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] |
|  | 2012 |  |  | 2011 |  |  | 2010 |
General and administrative expense |  | $ | 231,936 |  |  | $ | 284,352 |  |  | $ | 369,161 |
Research and development expense |  |  | 78,140 |  |  |  | 179,400 |  |  |  | 206,501 |
Total stock option expense |  | $ | 310,076 |  |  | $ | 463,752 |  |  | $ | 575,662 |
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] |
|  | Number of Shares |  |  | Weighted Average Exercise Price |
Outstanding at December 31, 2011 |  |  | 1,870,559 |  |  | $ | 7.96 |
Issued – Series A Warrants (1) |  |  | 2,933,333 |  |  |  | 1.00 |
Issued – Series B Warrants (1) |  |  | 2,933,333 |  |  |  | 0.75 |
Issued – Series C Warrants (1) |  |  | 2,933,333 |  |  |  | 1.00 |
Issued – Other Warrants (2) |  |  | 612,001 |  |  |  | 1.00 |
Exercised |  |  | -- |  |  |  | -- |
Forfeited or expired |  |  | (57,000 | ) |  |  | 7.00 |
Outstanding at December 31, 2012 |  |  | 11,225,559 |  |  | $ | 2.06 |
Exercisable at December 31, 2012 |  |  | 8,290,376 |  |  | $ | 2.44 |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph A240 -Subparagraph g(1) -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph 64 -Subparagraph b -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=6793087&loc=d3e301413-122809 + Details
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