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Note 3 - Government Grants (Detail) (USD $)
 3 Months Ended 12 Months Ended 138 Months Ended 12 Months Ended 59 Months Ended 12 Months Ended 12 Months Ended
Dec. 31, 2012
Sep. 30, 2012
Jun. 30, 2012
Mar. 31, 2012
Dec. 31, 2011
Sep. 30, 2011
Jun. 30, 2011
Mar. 31, 2011
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2012
Aug. 31, 2013
First NIH Grant [Member]
Aug. 31, 2012
First NIH Grant [Member]
Dec. 31, 2012
First NIH Grant [Member]
Aug. 31, 2013
Second NIH Grant [Member]
Dec. 31, 2012
Second NIH Grant [Member]
Dec. 31, 2012
NIH Grants [Member]
Dec. 31, 2011
NIH Grants [Member]
Dec. 31, 2010
NIH Grants [Member]
Dec. 31, 2010
QTDP Grant [Member]
Project Period Covered by Grants                           5 years   1 year          
Project Extension Period                         1 year                
Grant Award                           $ 20,400,000   $ 1,900,000         $ 244,479
Unused Grant Funds                             1,600,000   1,400,000        
Revenue from Grants $ 459,566 $ 638,000 $ 705,698 $ 854,063 $ 956,844 $ 1,297,006 $ 1,753,033 $ 893,002 $ 2,657,327 $ 4,899,885 $ 5,185,257 $ 22,969,019           $ 2,657,327 $ 4,899,885 $ 4,940,778