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Note 8 - Income Taxes (Details) - Deferred Tax Assets and Liabilities (USD $) | Dec. 31, 2012 | Dec. 31, 2011
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Deferred tax assets: |  |
Net operating loss carryforward | $ 24,429,472 | $ 24,872,082
Research and development tax credit carryforward | 764,000 | 763,690
Stock-based compensation expense | 2,097,194 | 1,991,769
Total deferred tax assets | 27,290,631 | 27,627,541
Deferred tax liabilities |  |
Depreciation | (16,125) | (36,311)
Total deferred tax liabilities | (16,125) | (36,311)
Net deferred tax assets | 27,274,506 | 27,591,230
Valuation allowance | $ (27,274,506) | $ (27,591,230)

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