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Note 5 - Stockholders' Equity (Tables) | 9 Months Ended | 12 Months Ended
--- | --- | ---
Sep. 30, 2013 | Dec. 31, 2012
Stockholders' Equity Note [Abstract] |  |
Common Stock Reserved For Future Issuance [Table Text Block] |
Common Stock Purchase Warrants |  |  | 8,292,226 |
Equity Incentive Plans |  |  | 1,197,529 |
Series A Convertible Preferred Stock |  |  | 1,050,667 |
Total |  |  | 10,540,422 |
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] |
|  | Number of Shares |  |  | Weighted Average Exercise Price |
Outstanding at December 31, 2012 |  |  | 1,069,141 |  |  | $ | 4.50 |
Granted |  |  | -- |  |  |  | -- |
Exercised |  |  | -- |  |  |  | -- |
Forfeited or expired |  |  | (78,429 | ) |  |  | 4.86 |
Outstanding at September 30, 2013 |  |  | 990,712 |  |  | $ | 4.47 |
Exercisable at September 30, 2013 |  |  | 679,036 |  |  | $ | 6.14 |
|  | Number of Shares |  |  | Weighted- Average Exercise Price |  |  | Weighted- Average Remaining Contractual Term (yrs) |  |  | Aggregate Intrinsic Value |
Outstanding at December 31, 2011 |  |  | 928,242 |  |  | $ | 5.43 |  |  |  |  |  |  |
Granted |  |  | 238,500 |  |  |  | 0.70 |  |  |  |  |  |  |
Exercised |  |  | - |  |  |  | - |  |  |  |  |  |  |
Forfeited or expired |  |  | (97,601 | ) |  |  | 4.02 |  |  |  |  |  |  |
Outstanding at December 31, 2012 |  |  | 1,069,141 |  |  | $ | 4.50 |  |  |  | 6.2 |  |  | $ | -0- |
Exercisable at December 31, 2012 |  |  | 698,995 |  |  | $ | 6.38 |  |  |  | 4.6 |  |  | $ | -0- |
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] |
|  | Number of Shares |  |  | Weighted Average Exercise Price |
Outstanding at December 31, 2012 |  |  | 11,225,559 |  |  | $ | 2.06 |
Issued |  |  | -- |  |  |  | -- |
Exercised |  |  | (2,933,333 | ) |  |  | 0.56 |
Forfeited or expired |  |  | -- |  |  |  | -- |
Outstanding at September 30, 2013 |  |  | 8,292,226 |  |  | $ | 2.53 |
Exercisable at September 30, 2013 |  |  | 8,292,226 |  |  | $ | 2.53 |
|  | Number of Shares |  |  | Weighted Average Exercise Price |
Outstanding at December 31, 2011 |  |  | 1,870,559 |  |  | $ | 7.96 |
Issued – Series A Warrants (1) |  |  | 2,933,333 |  |  |  | 1.00 |
Issued – Series B Warrants (1) |  |  | 2,933,333 |  |  |  | 0.75 |
Issued – Series C Warrants (1) |  |  | 2,933,333 |  |  |  | 1.00 |
Issued – Other Warrants (2) |  |  | 612,001 |  |  |  | 1.00 |
Exercised |  |  | -- |  |  |  | -- |
Forfeited or expired |  |  | (57,000 | ) |  |  | 7.00 |
Outstanding at December 31, 2012 |  |  | 11,225,559 |  |  | $ | 2.06 |
Exercisable at December 31, 2012 |  |  | 8,290,376 |  |  | $ | 2.44 |
Allocation of Net Proceeds from Preferred Stock Financing [Table Text Block] |  |
Net proceeds after transaction costs |  | $ | 1,999,032 |
Less: Fair value of warrants (recorded to Additional Paid-in Capital) |  |  | (1,127,418 | )
Beneficial conversion feature (recorded to Additional Paid-in Capital) |  |  | (762,667 | )
Net proceeds allocated to preferred stock |  |  | 108,947 |
Accretion of beneficial conversion feature (deemed dividend) |  |  | 762,667 |
Initial carrying value of preferred stock |  |  | 871,614 |
Conversions to common stock |  |  | (559,418 | )
Carrying value of preferred stock at December 31, 2012 |  | $ | 312,196 |
Additional Information Concerning Stock Options [Table Text Block] |  |
|  | 2012 |  |  | 2011 |  |  | 2010 |
Weighted average fair value of options granted during the period |  | $ | 0.59 |  |  | $ | 0.79 |  |  | $ | 2.95 |
Intrinsic value of options exercised during the period |  |  | - |  |  |  | - |  |  |  | - |
Total fair value of options vested during the period |  |  | 319,920 |  |  |  | 540,339 |  |  |  | 499,557 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |  |
|  | 2012 |  |  | 2011 |  |  | 2010 |
Weighted average risk-free interest rates |  |  | 1.1 | % |  |  | 1.4 | % |  |  | 2.6 | %
Expected dividend yield |  |  | 0.0 | % |  |  | 0.0 | % |  |  | 0.0 | %
Expected life of option (yrs) |  | 6.7 |  |  | 7 |  |  | 6.7 |
Expected volatility |  |  | 105.2 | % |  |  | 111.2 | % |  |  | 112.9 | %
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] |  |
|  | 2012 |  |  | 2011 |  |  | 2010 |
General and administrative expense |  | $ | 231,936 |  |  | $ | 284,352 |  |  | $ | 369,161 |
Research and development expense |  |  | 78,140 |  |  |  | 179,400 |  |  |  | 206,501 |
Total stock option expense |  | $ | 310,076 |  |  | $ | 463,752 |  |  | $ | 575,662 |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of warrants or rights issued. Warrants and rights outstanding are derivative securities that give the holder the right to purchase securities (usually equity) from the issuer at a specific price within a certain time frame. Warrants are often included in a new debt issue to entice investors by a higher return potential. The main difference between warrants and call options is that warrants are issued and guaranteed by the company, whereas options are exchange instruments and are not issued by the company. Also, the lifetime of a warrant is often measured in years, while the lifetime of a typical option is measured in months. Disclose the title of issue of securities called for by warrants and rights outstanding, the aggregate amount of securities called for by warrants and rights outstanding, the date from which the warrants or rights are exercisable, and the price at which the warrant or right is exercisable. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(i)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 08 -Paragraph i -Article 4 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 50 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6406099&loc=d3e25284-112666 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 50 -Section S99 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6784392&loc=d3e188667-122775 Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 28 -Article 5 + Details
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