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Note 5 - Stockholders' Equity (Tables)

9 Months Ended

12 Months Ended

Sep. 30, 2013

Dec. 31, 2012

Stockholders' Equity Note [Abstract]

Common Stock Reserved For Future Issuance [Table Text Block]

Common Stock Purchase Warrants			8,292,226
Equity Incentive Plans			1,197,529
Series A Convertible Preferred Stock			1,050,667
Total			10,540,422

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

		Number of Shares				Weighted Average Exercise Price
Outstanding at December 31, 2012			1,069,141			$	4.50
Granted			--				--
Exercised			--				--
Forfeited or expired			(78,429	)			4.86
Outstanding at September 30, 2013			990,712			$	4.47
Exercisable at September 30, 2013			679,036			$	6.14

		Number of Shares				Weighted- Average Exercise Price				Weighted- Average Remaining Contractual Term (yrs)				Aggregate Intrinsic Value
Outstanding at December 31, 2011			928,242			$	5.43
Granted			238,500				0.70
Exercised			-				-
Forfeited or expired			(97,601	)			4.02
Outstanding at December 31, 2012			1,069,141			$	4.50				6.2			$	-0-
Exercisable at December 31, 2012			698,995			$	6.38				4.6			$	-0-

Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]

		Number of Shares				Weighted Average Exercise Price
Outstanding at December 31, 2012			11,225,559			$	2.06
Issued			--				--
Exercised			(2,933,333	)			0.56
Forfeited or expired			--				--
Outstanding at September 30, 2013			8,292,226			$	2.53
Exercisable at September 30, 2013			8,292,226			$	2.53

		Number of Shares				Weighted Average Exercise Price
Outstanding at December 31, 2011			1,870,559			$	7.96
Issued – Series A Warrants (1)			2,933,333				1.00
Issued – Series B Warrants (1)			2,933,333				0.75
Issued – Series C Warrants (1)			2,933,333				1.00
Issued – Other Warrants (2)			612,001				1.00
Exercised			--				--
Forfeited or expired			(57,000	)			7.00
Outstanding at December 31, 2012			11,225,559			$	2.06
Exercisable at December 31, 2012			8,290,376			$	2.44

Allocation of Net Proceeds from Preferred Stock Financing [Table Text Block]

Net proceeds after transaction costs		$	1,999,032
Less:       Fair value of warrants (recorded to Additional Paid-in Capital)			(1,127,418	)
Beneficial conversion feature (recorded to Additional Paid-in Capital)			(762,667	)
Net proceeds allocated to preferred stock			108,947
Accretion of beneficial conversion feature (deemed dividend)			762,667
Initial carrying value of preferred stock			871,614
Conversions to common stock			(559,418	)
Carrying value of preferred stock at December 31, 2012		$	312,196

Additional Information Concerning Stock Options [Table Text Block]

		2012				2011				2010
Weighted average fair value of options granted during the period		$	0.59			$	0.79			$	2.95
Intrinsic value of options exercised during the period			-				-				-
Total fair value of options vested during the period			319,920				540,339				499,557

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		2012				2011				2010
Weighted average risk-free interest rates			1.1	%			1.4	%			2.6	%
Expected dividend yield			0.0	%			0.0	%			0.0	%
Expected life of option (yrs)		6.7				7				6.7
Expected volatility			105.2	%			111.2	%			112.9	%

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		2012				2011				2010
General and administrative expense		$	231,936			$	284,352			$	369,161
Research and development expense			78,140				179,400				206,501
Total stock option expense		$	310,076			$	463,752			$	575,662

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