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Note 6 - Stockholders' Equity (Details) - Stock-based Compensation Expense (USD $)
 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock option expense $ 310,076 $ 463,752 $ 575,662
General and Administrative Expense [Member]
      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock option expense 231,936 284,352 369,161
Research and Development Expense [Member]
      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock option expense $ 78,140 $ 179,400 $ 206,501