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Note 5 - Property and Equipment | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2017 | Dec. 31, 2016
Notes to Financial Statements |  |
Property, Plant and Equipment Disclosure [Text Block] | 5. Property and Equipment Property and equipment as shown on the accompanying Condensed Consolidated Balance Sheets is composed of the following as of March 31, 2017 and December 31, 2016:
|  | March 31, 2017 |  |  | December 31, 2016 |
Laboratory equipment |  | $ | 530,306 |  |  | $ | 525,956 |
Leasehold improvements |  |  | 115,605 |  |  |  | 115,605 |
Other furniture, fixtures & equipment |  |  | 28,685 |  |  |  | 28,685 |
Total property and equipment |  |  | 674,596 |  |  |  | 670,246 |
Accumulated depreciation and amortization |  |  | (622,316 | ) |  |  | (615,418 | )
Property and equipment, net |  | $ | 52,280 |  |  | $ | 54,828 |
| 3. Property and Equipment Property and equipment as shown on the accompanying Consolidated Balance Sheets is composed of the following as of December 31, 2016 and 2015:
|  | 2016 |  |  | 2015 |
Laboratory equipment |  | $ | 525,956 |  |  | $ | 525,956 |
Leasehold improvements |  |  | 115,605 |  |  |  | 115,605 |
Other furniture, fixtures & equipment |  |  | 28,685 |  |  |  | 28,685 |
Total property and equipment |  |  | 670,246 |  |  |  | 670,246 |
Accumulated depreciation and amortization |  |  | (615,418 | ) |  |  | (586,638 | )
Property and equipment, net |  | $ | 54,828 |  |  | $ | 83,608 |
Depreciation and leasehold amortization expense was $28,780, $28,935, and $59,037 during the years ended December 31, 2016, 2015 and 2014, respectively.

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- Definition The entire disclosure for long-lived, physical assets used in the normal conduct of business and not intended for resale. Includes, but is not limited to, accounting policies and methodology, roll forwards, depreciation, depletion and amortization expense, including composite depreciation, accumulated depreciation, depletion and amortization expense, useful lives and method used, income statement disclosures, assets held for sale and public utility disclosures. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -URI http://asc.fasb.org/topic&trid=2155823 + Details
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