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Note 5 - Government Grants and Contracts (Details Textual) - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2017 | Mar. 31, 2016 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Revenue from Grants | $ 295,735 | $ 47,600 | $ 828,918 | $ 428,081 | $ 882,956
NIH Grants [Member] |  |  |  |  |
Revenue from Grants | 295,735 | $ 47,600 | 828,918 | $ 428,081 | $ 882,956
Unused Grant Funds | $ 867,911 |  | $ 505,487 |  |

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- Definition The amount of grant funds available for use. + References No definition available. + Details
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- Definition Revenue earned during the period from non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.1(e)) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

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- Details
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Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |