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Note 8 - Stockholders' Equity - Common Stock Reserved for Future Issuance (Details) - shares | Mar. 31, 2017 | Dec. 31, 2016
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Common stock, reserved for future issuance (in shares) | 92,895,777 | 95,106,312
Series B Convertible Preferred Stock [Member] |  |
Common stock, reserved for future issuance (in shares) | 285,714 | 285,714
Series C Convertible Preferred Stock [Member] |  |
Common stock, reserved for future issuance (in shares) | 57,363,520 | 57,363,520
Warrant [Member] |  |
Common stock, reserved for future issuance (in shares) | 30,656,243 | 32,751,578
Equity Incentive Plans [Member] |  |
Common stock, reserved for future issuance (in shares) | 4,590,300 | 4,705,500

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- Definition Aggregate number of common shares reserved for future issuance. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.29) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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