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Note 11 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2016

Notes Tables

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

		2016				2015
Deferred tax assets:
Net operating loss carryforward		$	24,689,298			$	23,822,431
Research and development tax credit carryforward			892,231				893,797
Stock-based compensation expense			2,748,899				2,419,892
Depreciation			1,331				-
Total deferred tax assets			28,331,759				27,136,120
Deferred tax liabilities
Depreciation			-				(5,086	)
Total deferred tax liabilities			-				(5,086	)
Net deferred tax assets			28,331,759				27,131,034
Valuation allowance			(28,331,759	)			(27,131,034	)
		$	-0-			$	-0-

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

		2016				2015				2014
U.S. federal statutory rate applied to pretax loss		$	(1,112,378	)		$	(936,936	)		$	(906,830	)
Permanent differences			2,012				2,914				1,734
Research and development credits			59,087				67,901				26,648
Change in valuation allowance			1,051,279				866,121				878,448
Reported income tax expense		$	-0-			$	-0-			$	-0-

X

- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319

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- Definition

Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319

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