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Note 9 - Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2016
Notes Tables |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | 2016 |  |  | 2015 |  |  | 2014 |
Weighted average risk-free interest rates |  |  | 2.26 | % |  |  | 1.99 | % |  |  | 1.98 | %
Expected dividend yield |  |  | 0.0 | % |  |  | 0.0 | % |  |  | 0.0 | %
Expected life of option (yrs ) |  | 7.0 |  |  | 7.0 |  |  | 7.0 |
Expected volatility |  |  | 88.72 | % |  |  | 91.43 | % |  |  | 94.88 | %
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] |
|  | 2016 |  |  | 2015 |  |  | 2014 |
General and administrative expense |  | $ | 31,191 |  |  | $ | 45,822 |  |  | $ | 69,057 |
Research and development expense |  |  | 23,614 |  |  |  | 22,083 |  |  |  | 32,134 |
Total stock option expense |  | $ | 54,805 |  |  | $ | 67,905 |  |  | $ | 101,191 |
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] |
|  | 2016 |  |  | 2015 |  |  | 2014 |
Weighted average fair value of options granted |  | $ | 0.05 |  |  | $ | 0.09 |  |  | $ | 0.14 |
Intrinsic value of options exercised |  |  | -0- |  |  |  | -0- |  |  |  | -0- |
Total fair value of options vested |  |  | 54,757 |  |  |  | 66,622 |  |  |  | 97,707 |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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