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Note 11 - Income Taxes (Details Textual) - USD ($) | 12 Months Ended | 198 Months Ended
--- | --- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2017
Income Tax Expense (Benefit) |  | $ 0 | $ 0 | $ 0 | $ 0
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent | 21.00% | 35.00% |  |  |
Deferred Tax Assets from Remeasurement due to Changes in Enacted Tax Rate |  | $ (10,100,000) |  |  |
Deferred Tax Assets from Remeasurement due to Changes in Enacted Tax Rate [Member] |  |  |  |  |
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount |  | (10,100,000) |  |  |
Scenario, Forecast [Member] |  |  |  |  |
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent | 21.00% |  |  |  |
Research Tax Credit Carryforward [Member] |  |  |  |  |
Tax Credit Carryforward, Amount |  | 949,000 |  |  | 949,000
Domestic Tax Authority [Member] |  |  |  |  |
Operating Loss Carryforwards |  | $ 70,900,000 |  |  | $ 70,900,000

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- Definition Percentage of domestic federal statutory tax rate applicable to pretax income (loss). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 6.I) -URI http://asc.fasb.org/extlink&oid=34349781&loc=d3e330036-122817 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32698-109319 + Details
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