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Note 11 - Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforward | $ 16,273,259 | $ 24,689,298
Research and development tax credit carryforward | 949,340 | 892,231
Stock-based compensation expense | 1,709,867 | 2,748,899
Accrued salaries and directors’ fees | 185,961 |
Depreciation | 5,532 | 1,331
Total deferred tax assets | 19,123,959 | 28,331,759
Deferred tax liabilities |  |
Net deferred tax assets | 19,123,959 | 28,331,759
Valuation allowance | (19,123,959) | (28,331,759)
Net deferred tax asset after reduction for valuation allowance | $ 0 | $ 0

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