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Note 11 - Income Taxes (Details Textual) - USD ($)
 12 Months Ended 198 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2017
Income Tax Expense (Benefit)   $ 0 $ 0 $ 0 $ 0
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent 21.00% 35.00%      
Deferred Tax Assets from Remeasurement due to Changes in Enacted Tax Rate   $ (10,100,000)      
Deferred Tax Assets from Remeasurement due to Changes in Enacted Tax Rate [Member]          
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount   (10,100,000)      
Scenario, Forecast [Member]          
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent 21.00%        
Research Tax Credit Carryforward [Member]          
Tax Credit Carryforward, Amount   949,000     949,000
Domestic Tax Authority [Member]          
Operating Loss Carryforwards   $ 70,900,000     $ 70,900,000