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Note 8 - Common Stock (Details Textual) - USD ($) | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Stock Issued During Period, Shares, Issued for Services | 17,500,000 |  |
Common Stock, Capital Shares Reserved for Future Issuance | 265,565,942 |  |
2006 Equity Incentive Plan [Member] |  |  |
Common Stock, Capital Shares Reserved for Future Issuance | 1,412,300 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period | 10 years |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period | 3 years |  |
2006 Equity Incentive Plan [Member] | Incentive Stock Options (ISO's) [Member] |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent | 110.00% |  |
Equity Incentive Plan 2016 [Member] |  |  |
Common Stock, Capital Shares Reserved for Future Issuance | 16,000,000 |  |
Expense Associated with Warrant Modifications [Member] |  |  |
Stock Issued During Period, Shares, Warrants Exercised |  | 31,639,577 | 21,884,420
Proceeds from Warrant Exercises |  | $ 571,511 | $ 1,339,801
Conversion from Series C and Series D Convertible Preferred Stock to Common Stock [Member] |  |  |
Conversion of Stock, Shares Issued | 94,666,666 | 19,862,000 | 1,400,000

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