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Note 11 - Income Taxes (Details Textual) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Income Tax Expense (Benefit), Total | $ 0 | $ 0 | $ 0
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent | 21.00% | 35.00% |
Deferred Tax Assets from Remeasurement due to Changes in Enacted Tax Rate | $ (10,100,000) |  |
Deferred Tax Assets from Remeasurement due to Changes in Enacted Tax Rate [Member] |  |  |
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount | (10,100,000) |  |
Research Tax Credit Carryforward [Member] |  |  |
Tax Credit Carryforward, Amount | 1,064,000 |  |
Domestic Tax Authority [Member] |  |  |
Operating Loss Carryforwards, Total | $ 72,500,000 |  |

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