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Note 3 - Property and Equipment - Schedule of Property and Equipment (Details) - USD ($) | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Property and equipment, gross | $ 674,596 | $ 674,596
Accumulated depreciation and amortization | (663,246) | (643,445)
Property and equipment, net | 11,350 | 31,151
Laboratory Equipment [Member] |  |
Property and equipment, gross | 530,306 | 530,306
Leasehold Improvements [Member] |  |
Property and equipment, gross | 115,605 | 115,605
Other Furniture Fixtures And Equipment [Member] |  |
Property and equipment, gross | $ 28,685 | $ 28,685

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