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Note 11 - Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforward | $ 16,681,908 | $ 16,273,259
Research and development tax credit carryforward | 1,063,877 | 949,340
Stock-based compensation expense | 1,808,509 | 1,709,867
Accrued salaries and directors’ fees | 317,246 | 185,961
Depreciation | 8,414 | 5,532
Total deferred tax assets | 19,879,954 | 19,123,959
Deferred tax liabilities |  |
Net deferred tax assets | 19,879,954 | 19,123,959
Valuation allowance | (19,879,954) | (19,123,959)
Net deferred tax asset after reduction for valuation allowance | $ 0 | $ 0

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