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Note 5 - Property and Equipment - Schedule of Property and Equipment (Details) - USD ($)
Mar. 31, 2019
Dec. 31, 2018
Property and equipment, gross $ 678,868 $ 674,596
Accumulated depreciation and amortization (665,143) (663,246)
Property and equipment, net 13,725 11,350
Laboratory Equipment [Member]    
Property and equipment, gross 534,578 530,306
Leasehold Improvements [Member]    
Property and equipment, gross 115,605 115,605
Other Furniture Fixtures And Equipment [Member]    
Property and equipment, gross $ 28,685 $ 28,685