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Note 9 - Stockholders' Equity (Details Textual) - USD ($)
 1 Months Ended 2 Months Ended 3 Months Ended
Feb. 28, 2019
Feb. 26, 2019
Feb. 18, 2019
Mar. 31, 2019
Feb. 28, 2019
Mar. 31, 2019
Mar. 31, 2018
Feb. 25, 2019
Dec. 31, 2018
Feb. 28, 2018
Preferred Stock, Par or Stated Value Per Share       $ 0.01   $ 0.01     $ 0.01  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance       29,441   29,441        
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance       $ 53.19   $ 53.19        
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number       13,585   13,585        
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price       $ 93.92   $ 93.92        
Share-based Payment Arrangement, Expense           $ 26,652 $ 23,978      
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total       $ 183,731   $ 183,731        
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition           2 years        
Stock Issued During Period, Value Expensed During the Period, Issued for Services           $ 126,572 $ 28,571      
Prepaid Expense, Value of Stock Issued for Services During Period       $ 72,509   $ 72,509        
Series I Warrants [Member]                    
Convertible Preferred Stock and Related Warrants Issued   33,334                
Class of Warrant or Right, Exercise Price of Warrants or Rights   $ 7.50                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights   66,668                
Common Stock Purchase Warrants [Member]                    
Class of Warrant or Right, Number of Securities Called by Warrants or Rights                   358
Class Of Warrant Or Right Issued During Period           33,334        
Class of Warrant or Right, Outstanding       148,032   148,032        
Class Of Warrant Or Right Outstanding Weighted Average Exercise Price       $ 11.54   $ 11.54        
Class Of Warrant Or Right Exercisable Number       94,698   94,698        
Class Of Warrant Or Right Exercisable Weighted Average Exercise Price       $ 12.75   $ 12.75        
Series G Convertible Preferred Stock and Related Warrants [Member]                    
Convertible Preferred Stock and Related Warrants, Authorized 1,000                  
Proceeds from Issuance of Convertible Preferred Stock and Related Warrants, Maximum $ 1,000,000 $ 250,000                
Convertible Preferred Stock and Related Warrants Issued   500                
Conversion of Series C Preferred Stock Into Common Stock [Member]                    
Conversion of Stock, Shares Converted         587 587        
Conversion of Stock, Shares Issued         78,280 78,280        
Conversion of Series F Preferred Stock Into Common Stock [Member]                    
Conversion of Stock, Shares Converted       180   180        
Conversion of Stock, Shares Issued       40,000   40,000        
Conversion from Series C and F Convertible Preferred Stock to Common Stock [Member]                    
Conversion of Stock, Shares Issued           118,280        
Series B Convertible Preferred Stock [Member]                    
Preferred Stock, Shares Outstanding, Ending Balance       100   100     100  
Convertible Preferred Stock, Conversion Price1       $ 175   $ 175        
Conversion of Stock, Shares Converted           0        
Preferred Stock, Par or Stated Value Per Share       $ 1,000   $ 1,000     $ 1,000  
Series F Convertible Preferred Stock [Member]                    
Preferred Stock, Shares Outstanding, Ending Balance       2,583   2,583        
Convertible Preferred Stock, Conversion Price1     $ 7.50              
Number of Series C and Series E Preferred Stock Exchanged for Series F Convertible Preferred Stock     2,763              
Preferred Stock, Par or Stated Value Per Share     $ 1,000              
Convertible Preferred Stock, Conversion Price, Percentage of Volume Weighted Average Price of the Common Stock     90.00%              
Series E Convertible Preferred Stock [Member]                    
Preferred Stock, Shares Outstanding, Ending Balance       0   0     1,200  
Preferred Stock, Par or Stated Value Per Share       $ 1,000   $ 1,000     $ 1,000  
Series G Convertible Preferred Stock [Member]                    
Convertible Preferred Stock, Conversion Price1               $ 7.50    
Conversion of Stock, Shares Converted           0        
Preferred Stock, Par or Stated Value Per Share               $ 1,000    
Convertible Preferred Stock, Conversion Price, Percentage of Volume Weighted Average Price of the Common Stock               90.00%    
Series C Convertible Preferred Stock [Member]                    
Preferred Stock, Shares Outstanding, Ending Balance       0   0     2,150  
Preferred Stock, Par or Stated Value Per Share       $ 1,000   $ 1,000     $ 1,000