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Note 12 - Grants and Collaboration Revenue (Details Textual) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Revenue from Contract with Customer, Including Assessed Tax $ 333,209 $ 349,344 $ 907,382 $ 663,908
NIH Grants [Member]        
Revenue from Contract with Customer, Including Assessed Tax 214,765 340,716 754,022 650,280
Unused Grant Funds 1,835,225   1,835,225  
Research Agreements [Member]        
Revenue from Contract with Customer, Including Assessed Tax $ 118,444 $ 8,628 $ 153,360 $ 13,628