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Note 7 - Stockholders' Equity (Details Textual) - USD ($) |  |  |  |  |  |  |  | 1 Months Ended | 2 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jul. 24, 2019 | Jul. 16, 2019 | Jun. 19, 2019 | Apr. 26, 2019 | Feb. 26, 2019 | Feb. 25, 2019 | Feb. 18, 2019 | Jul. 31, 2019 | Feb. 28, 2019 | Sep. 30, 2018 | Mar. 31, 2018 | May 31, 2017 | Feb. 28, 2019 | Dec. 31, 2019 | Dec. 31, 2018
Preferred Stock, Shares Authorized |  |  |  |  |  |  |  |  |  |  |  |  |  | 10,000,000 | 10,000,000
Preferred Stock, Par or Stated Value Per Share |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01
Preferred Stock, Shares Outstanding, Ending Balance |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,486 | 3,450
Conversion of Stock, Shares Issued |  |  |  |  |  |  |  |  |  |  |  |  |  | 296,390 | 95
Stock Issued During Period, Shares, Issued for Services |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,224 | 17
Stock Issued During Period, Value, Issued for Services |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 24,000 | $ 513,500
Stock Issued During Period, Value Expensed During the Period, Issued for Services |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 314,419
Prepaid Expense, Value of Stock Issued for Services During Period |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 199,080 |
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent |  |  |  |  |  |  |  |  |  |  |  |  |  | 110.00% |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  |  |  |  |  |  |  |  |  |  |  |  | 10 years |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  |  |  |  |  |  |  |  |  |  |  |  |  | 3 years |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 99,975 |
Series I Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  |  |  |  |  |  |  |  |  |  |  | 48 |
Class of Warrant or Right, Exercise Price of Warrants or Rights |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 15,000 |
Share-based Payment Arrangement, Option [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Payment Arrangement, Expense |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 104,420 | 155,304
Share-based Payment Arrangement, Option [Member] | Research and Development Expense [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Payment Arrangement, Expense |  |  |  |  |  |  |  |  |  |  |  |  |  | 43,801 | 41,998
Share-based Payment Arrangement, Option [Member] | General and Administrative Expense [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Payment Arrangement, Expense |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 60,619 | $ 113,306
Series G Convertible Preferred Stock and Related Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Preferred Stock and Related Warrants, Authorized |  |  |  |  |  | 1,000 |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Convertible Preferred Stock and Related Warrants, Maximum |  |  | $ 500,000 | $ 500,000 | $ 250,000 | $ 1,000,000 |  |  |  |  |  |  |  |  |
Convertible Preferred Stock and Related Warrants Issued |  |  | 500 | 500 | 500 |  |  |  |  |  |  |  |  |  |
Series I Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Preferred Stock and Related Warrants Issued |  |  | 500 |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Series C Preferred Stock Into Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted |  |  |  |  |  |  |  |  |  |  |  |  | 587 |  | 420
Conversion of Stock, Shares Issued |  |  |  |  |  |  |  |  |  |  |  |  | 39 |  | 28
Conversion of Series C Preferred Stock Into Series F Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted |  |  |  |  |  |  |  |  | 1,563 |  |  |  |  |  |
Conversion of Series D Preferred Stock Into Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Issued |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 67
Conversion of Series E Preferred Stock Into Series F Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted |  |  |  |  |  |  |  |  | 1,200 |  |  |  |  |  |
Conversion of Series F Preferred Stock Into Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted |  |  |  |  |  |  |  |  |  |  |  |  |  | 507 |
Conversion of Stock, Shares Issued |  |  |  |  |  |  |  |  |  |  |  |  |  | 191 |
Conversion from Series F Preferred Stock to Series H Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted |  |  |  |  |  |  |  | 2,256 |  |  |  |  |  |  |
Conversion of Series H Preferred Stock Into Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,570 |
Conversion of Stock, Shares Issued |  |  |  |  |  |  |  |  |  |  |  |  |  | 296,160 |
Conversion of Series I Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |
Series B Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Par or Stated Value Per Share |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,000 |
Preferred Stock, Shares Outstanding, Ending Balance |  |  |  |  |  |  |  |  |  |  |  |  |  | 100 | 100
Convertible Preferred Stock, Conversion Price1 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 350,000 |
Series D Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Par or Stated Value Per Share |  |  |  |  |  |  |  |  |  |  |  | $ 1,000 |  |  |
Stock Issued During Period, Shares, New Issues |  |  |  |  |  |  |  |  |  |  |  | 1,000 |  |  |
Proceeds From Issuance Of Convertible Preferred Stock, Net of Issuance Cost |  |  |  |  |  |  |  |  |  |  |  | $ 980,000 |  |  |
Series E Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Par or Stated Value Per Share |  |  |  |  |  |  |  |  |  |  | $ 1,000 |  |  | $ 1,000 |
Preferred Stock, Shares Outstanding, Ending Balance |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,200
Stock Issued During Period, Shares, New Issues |  |  |  |  |  |  |  |  |  | 600 | 600 |  |  |  |
Proceeds From Issuance Of Convertible Preferred Stock, Net of Issuance Cost |  |  |  |  |  |  |  |  |  | $ 600,000 | $ 590,000 |  |  |  |
Series F Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of Series C and Series E Preferred Stock Exchanged for Series F Convertible Preferred Stock |  |  |  |  |  |  | 2,763 |  |  |  |  |  |  |  |
Series G Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Outstanding, Ending Balance |  |  |  |  |  |  |  | 1,000 |  |  |  |  |  |  |
Series H Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Par or Stated Value Per Share |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,000 |
Preferred Stock, Shares Outstanding, Ending Balance |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,686 |
Convertible Preferred Stock, Conversion Price1 |  | $ 15,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Issued |  | 3,257 |  |  |  |  |  |  |  |  |  |  |  |  |
Series I Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Par or Stated Value Per Share |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,000 |
Preferred Stock, Shares Outstanding, Ending Balance |  |  |  |  |  |  |  |  |  |  |  |  |  | 700 |
Convertible Preferred Stock, Conversion Price1 | $ 15,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues | 700 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Preferred Stock and Preference Stock | $ 700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Series C Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Par or Stated Value Per Share |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,000 |
Preferred Stock, Shares Outstanding, Ending Balance |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,150

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