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Note 6 - Stock-based Compensation Expense (Tables)
6 Months Ended
Jun. 30, 2022
Notes Tables  
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
   

Three Months Ended June 30,

   

Six Months Ended June 30,

 
   

2022

   

2021

   

2022

   

2021

 

Stock options:

                               

Research and development

  $ 54,293     $ 21,468     $ 108,585     $ 42,936  

General and administrative

    135,898       34,722       271,797       69,444  

Total stock option expense

    190,191       56,190       380,382       112,380  

Stock awards (consultants):

                               

General and administrative

    16,987       30,573       31,947       51,173  

Total stock-based compensation expense

  $ 207,178     $ 86,763     $ 412,329     $ 163,553