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Note 8 - Stockholders' Equity (Details Textual) |  |  |  |  |  |  |  |  |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |
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Feb. 11, 2021 $ / shares shares | Sep. 29, 2020 USD ($) $ / shares shares | Sep. 25, 2020 | Sep. 24, 2020 USD ($) $ / shares shares | Jan. 21, 2020 | Apr. 30, 2019 | Apr. 26, 2019 USD ($) shares | Feb. 26, 2019 USD ($) | Feb. 25, 2019 USD ($) | Jul. 31, 2020 shares | Jan. 31, 2020 USD ($) shares | Jul. 31, 2019 USD ($) shares | Feb. 28, 2019 shares | Sep. 30, 2021 USD ($) $ / shares shares | Sep. 30, 2020 USD ($) | Sep. 30, 2021 USD ($) $ / shares shares | Sep. 30, 2020 USD ($) | Dec. 31, 2020 USD ($) $ / shares shares | Dec. 31, 2019 USD ($) $ / shares shares | Jun. 26, 2020 $ / shares shares
Preferred Stock, Shares Authorized (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10,000,000 | 10,000,000 |
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.01 |  | $ 0.01 |  | $ 0.01 | $ 0.01 |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100 | 2,486 |
Stock Issued During Period, Shares, New Issues (in shares) | 1,644,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance or Sale of Equity, Gross | $ |  |  |  | $ 12,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance or Sale of Equity, Total | $ |  |  |  | $ 11,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of Common Stock Securities Called by Each Unit (in shares) |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares Issued, Price Per Share (in dollars per share) | $ / shares | $ 6.25 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred Compensation Liability Conversion to Equity, Amount | $ |  | $ 1,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred Compensation Liability Conversion to Equity, Conversion Price (in dollars per share) | $ / shares |  | $ 5.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Cancellation of Accrued Compensation (in shares) |  | 300,001 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Conversion of Convertible Securities (in shares) |  | 177,626 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Issued for Services (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 13,707 |  | 26,581 | 162 |
Stock Issued During Period, Shares, Warrants Exercised (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 36,902 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 110.00% |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period (Year) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10 years |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3 years |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.12 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  | 602,000 | 0 |
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 655,510 |  |
Class of Warrant or Right, Outstanding (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,600,337 |  |
Prepaid Expense, Value of Stock Issued for Services During Period | $ |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 39,773 |  | $ 39,773 |  | $ 48,667 |  |
Expense Related To Consulting And Investment Banking Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Payment Arrangement, Expense | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 45,733 | $ 223,080 |
Share-based Payment Arrangement, Option [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Payment Arrangement, Expense | $ |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 56,190 | $ 0 | $ 168,570 | $ 0 | $ 18,730 | $ 104,420 |
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 years 2 months 12 days |  | 2 years 10 months 24 days |  |
Stock Incentive Plan 2020 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock, Capital Shares Reserved for Future Issuance (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500,000 |  | 1,500,000 |  | 1,000,000 |  |
Conversion from Convertible Debentures to Conversion Units [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Conversion, Converted Instrument, Principal and Interest, Amount | $ |  | $ 1,214,667 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Warrant Or Right, Issued During Period (in shares) |  |  |  | 2,560,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion Warrants [Member] | Conversion from Convertible Debentures to Conversion Units [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Conversion, Converted Instrument, Warrants or Options Issued (in shares) |  | 303,668 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unit Warrant [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right (in shares) |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  | $ 5.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding, Term (Year) |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Pre-Funded Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right (in shares) |  | 1 |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  | $ 0.01 |  | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.01 |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 250,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Outstanding (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 126,042 |  |
Pre-Funded Warrants [Member] | Conversion from Convertible Debentures to Conversion Units [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Conversion, Converted Instrument, Warrants or Options Issued (in shares) |  | 126,042 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Representative Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | $ 6.875 |  |  | $ 5.50 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 5.50 |  |
Warrants and Rights Outstanding, Term (Year) |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 72,000 | 128,000 |  | 128,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Period for Warrants or Rights Exercisable (Day) |  |  |  | 180 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Outstanding (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 128,000 |  |
Management Warrant [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 300,001 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of Warrants Called by Each Unit (in shares) |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Series I Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 5.00 |  |
Stock Issued During Period, Shares, Warrants Exercised (in shares) |  |  |  |  |  |  |  |  |  | 29,755 |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Outstanding (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 62,626 |  |
June 2020 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  | $ 5.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 5.00 |  | $ 10.00
Warrants and Rights Outstanding, Term (Year) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 120,000
Class of Warrant or Right, Outstanding (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 120,000 |  |
Unit Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right (in shares) |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  | $ 5.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding, Term (Year) |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 2,560,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio |  |  | 20 |  | 2,000 | 500 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Series G Convertible Preferred Stock and Related Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Preferred Stock and Related Warrants, Authorized (in shares) |  |  |  |  |  |  |  |  |  |  |  |  | 1,000 |  |  |  |  |  |  |
Proceeds from Issuance of Convertible Preferred Stock and Related Warrants, Maximum | $ |  |  |  |  |  |  |  | $ 250,000 | $ 1,000,000.0 |  |  |  |  |  |  |  |  |  |  |
Convertible Preferred Stock and Related Warrants Issued (in shares) |  |  |  |  |  |  | 500 |  |  |  |  |  | 500 |  |  |  |  |  |  |
Series G Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Convertible Preferred Stock and Related Warrants, Maximum | $ |  |  |  |  |  |  | $ 500,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Capital Units [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  |  | 2,560,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares Issued, Price Per Share (in dollars per share) | $ / shares |  |  |  | $ 5.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Series C Preferred Stock Into Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 587 |
Conversion of Stock, Shares Issued (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 |
Conversion of Series C Preferred Stock Into Series F Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,563 |
Conversion of Series E Preferred Stock Into Series F Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,200 |
Conversion of Series F Preferred Stock Into Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 507 |
Conversion of Stock, Shares Issued (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 9 |
Conversion from Series F Preferred Stock to Series H Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,256 |
Conversion of Series H Preferred Stock Into Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,686 | 1,570 |
Conversion of Stock, Shares Issued (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 469,697 | 14,808 |
Conversion of Series I Preferred Stock Into Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 700 |  |
Conversion of Stock, Shares Issued (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 204,371 |  |
Conversion of Series J Preferred Stock into Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 300 |  |
Conversion of Stock, Shares Issued (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 42,723 |  |
Conversion of Series H, Series I, and Series J Preferred Stock into Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Issued (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 716,790 | 14,819 |
Series B Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Authorized (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  | 10,000,000 |  | 10,000,000 |  | 10,000,000 |  |
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,000 |  | $ 1,000 |  | $ 1,000 |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  | 0 |  | 100 | 100 |
Convertible Preferred Stock, Conversion Price1 (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 7,000,000 |  |
Series C Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,000 |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |
Series E Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,000 |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |
Series F Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |
Number of Series C and Series E Preferred Stock Exchanged for Series F Convertible Preferred Stock (in shares) |  |  |  |  |  |  |  |  |  |  |  |  | 2,763 |  |  |  |  |  |  |
Series G Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) |  |  |  |  |  |  |  |  |  |  |  | 1,000 |  |  |  |  |  | 0 |  |
Series H Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 1,686 |
Conversion of Stock, Shares Issued (in shares) |  |  |  |  |  |  |  |  |  |  |  | 3,256 |  |  |  |  |  |  |  |
Series I Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 700 |
Stock Issued During Period, Shares, New Issues (in shares) |  |  |  |  |  |  |  |  |  |  |  | 700 |  |  |  |  |  |  |  |
Proceeds from Issuance of Preferred Stock and Preference Stock | $ |  |  |  |  |  |  |  |  |  |  |  | $ 700,000 |  |  |  |  |  |  |  |
Series J Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  |  |  |  |  |  |  |  |  | 300 |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Preferred Stock and Preference Stock | $ |  |  |  |  |  |  |  |  |  |  | $ 300,000 |  |  |  |  |  |  |  |  |
Capital Units Tranche One [Member] | Capital Units [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  |  | 2,310,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of Common Stock Securities Called by Each Unit (in shares) |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Capital Units Tranche Two [Member] | Capital Units [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  |  | 250,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Units Including Pre-Funded Warrants [Member] | Capital Units [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares Issued, Price Per Share (in dollars per share) | $ / shares |  |  |  | $ 4.99 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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