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Note 2 - Summary of Significant Accounting Policies (Details Textual) |  |  | 12 Months Ended
--- | --- | --- | ---
Sep. 25, 2020 | Jan. 21, 2020 | Dec. 31, 2021 USD ($) shares | Dec. 31, 2020 USD ($) shares
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares |  |  | 213,831 | 1,001,948
Research and Development Expense, Total |  |  | $ 15,554,171 | $ 2,444,459
Upfront Fees for COH and PNP License[Member] |  |  |  |
Research and Development Expense, Total |  |  | $ 10,513,825 |
Minimum [Member] |  |  |  |
Property, Plant and Equipment, Useful Life (Year) |  |  | 3 years |
Maximum [Member] |  |  |  |
Property, Plant and Equipment, Useful Life (Year) |  |  | 5 years |
Reverse Stock Split [Member] |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio | 20 | 2,000 |  |

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- Definition Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=124432515&loc=d3e3550-109257 + Details
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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 912 -SubTopic 730 -Section 25 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6472174&loc=d3e58812-109433 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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