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Note 6 - Stock-Based Compensation Expense - Schedule of Stock-Based Compensation Expense (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021
Total stock-based compensation expense | $ 902,074 | $ 369,987
Share-Based Payment Arrangement, Option [Member] |  |
Total stock-based compensation expense | 773,377 | 269,427
Share-Based Payment Arrangement, Option [Member] | Research and Development Expense [Member] |  |
Total stock-based compensation expense | 225,031 | 96,814
Share-Based Payment Arrangement, Option [Member] | General and Administrative Expense [Member] |  |
Total stock-based compensation expense | 548,346 | 172,613
Restricted Stock [Member] | General and Administrative Expense [Member] |  |
Total stock-based compensation expense | $ 128,697 | $ 100,560

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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