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Note 6 - Stockholders' Equity (Details Textual) |  |  |  |  |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | --- | --- | ---
Aug. 30, 2024 USD ($) $ / shares shares | Aug. 21, 2024 USD ($) $ / shares shares | Jul. 12, 2024 USD ($) $ / shares shares | May 21, 2024 USD ($) $ / shares shares | Jan. 16, 2024 shares | Dec. 02, 2023 USD ($) $ / shares shares | Aug. 31, 2024 USD ($) shares | Jun. 30, 2024 USD ($) shares | Jan. 31, 2024 shares | Dec. 31, 2024 USD ($) shares | Dec. 31, 2023 USD ($) shares
Common Stock, Shares Authorized (in shares) |  |  |  |  | 150,000,000 |  |  |  |  | 150,000,000 | 600,000,000
Class of Warrant or Right, Outstanding |  |  |  |  |  |  |  |  |  | 6,617,747 |
Proceeds from Warrant Exercises | $ |  |  |  |  |  |  |  |  |  | $ 2,367,133 | $ 4,062,442
Stock Issued During Period, Shares, Issued for Services (in shares) |  |  |  |  |  |  |  |  |  | 6,703 | 24,021
Stock Issued During Period, Shares, Reverse Stock Splits (in shares) |  |  |  |  |  |  |  |  | 55,422 |  |
Common Stock, Capital Shares Reserved for Future Issuance |  |  |  |  |  |  |  |  |  | 8,651,395 |
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent |  |  |  |  |  |  |  |  |  | 110.00% |
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period |  |  |  |  |  |  |  |  |  | 10 years |
Stock Incentive Plan 2020 [Member] |  |  |  |  |  |  |  |  |  |  |
Common Stock, Capital Shares Reserved for Future Issuance |  |  |  |  |  |  |  |  |  | 2,033,648 |
May 2024 Pre-funded Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  | 582,844 |  |  |  |  |  |  |
Stock Issued During Period, Shares, Warrant Exercise |  |  |  |  |  |  |  | 582,844 |  |  |
May 2024 Common Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  | $ 1.68 |  |  |  |  |  |  |
May 2024 Common Warrants [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  | 1,605,688 |  |  |  |  |  |  |
July 2024 Pre-funded Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  | 626,368 |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Warrant Exercise |  |  |  |  |  |  | 626,368 |  |  |  |
July 2024 Common Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  | $ 2.86 |  |  |  |  |  |  |  |
July 2024 Common Warrants [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  | 2,170,000 |  |  |  |  |  |  |  |
August 21, 2024 Prefunded Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 339,269 |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Warrant Exercise |  |  |  |  |  |  | 477,379 |  |  |  |
August 21 2024 Common Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  | $ 5 |  |  |  |  |  |  |  |  |
August 21 2024 Common Warrants [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 1,700,000 |  |  |  |  |  |  |  |  |
August 30 2024 Prefunded Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 138,110 |  |  |  |  |  |  |  |  |  |
August 30 2024 Common Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | $ 5 |  |  |  |  |  |  |  |  |  |
August 30 2024 Common Warrants [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 975,610 |  |  |  |  |  |  |  |  |  |
January 2022 and May 2022 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  |  |  | 704,499 |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  | $ 6.21 |  |  |  |  |
Class of Warrant or Right, Outstanding |  |  |  |  |  | 1,408,998 |  |  |  |  |
Stock Issued During Period, Shares, Warrant Exercise |  |  |  |  |  | 197,467 |  |  |  |  |
December 2023 Warrant [Member] |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  | $ 6.21 |  |  |  |  |
Class of Warrant or Right, Outstanding |  |  |  |  |  | 507,032 |  |  |  |  |
December 2023 Warrant Exercise Inducement [Member] |  |  |  |  |  |  |  |  |  |  |
Proceeds from Warrant Exercises | $ |  |  |  |  |  | $ 4,100,000 |  |  |  |  |
Warrants Issued in June 2020 [Member] |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Warrant Cashless Exercise (in shares) |  |  |  |  |  |  | 3,398 | 2,549 |  |  |
Class of Warrant or Right, Warrants Exercised (in shares) |  |  |  |  |  |  | 4,000 | 4,000 |  |  |
Warrants Issued in December 2023 [Member] |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Warrant Exercise |  |  |  |  |  |  | 582,000 | 826,998 |  |  |
Proceeds from Warrant Exercises | $ |  |  |  |  |  |  | $ 978,000 | $ 1,400,000 |  |  |
May 2024 Offering [Member] |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  |  | 220,000 |  |  |  |  |  |  |
Proceeds from Issuance or Sale of Equity | $ |  |  |  | $ 1,200,000 |  |  |  |  |  |  |
July 2024 Offering [Member] |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  | 458,632 |  |  |  |  |  |  |  |
Proceeds from Issuance or Sale of Equity | $ |  |  | $ 2,800,000 |  |  |  |  |  |  |  |
August 21 2024 Offering [Member] |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  | 1,360,731 |  |  |  |  |  |  |  |  |
Proceeds from Issuance or Sale of Equity | $ |  | $ 7,900,000 |  |  |  |  |  |  |  |  |
August 30 2024 Offering [Member] |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) | 837,500 |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance or Sale of Equity | $ | $ 4,600,000 |  |  |  |  |  |  |  |  |  |
At-the-Market Program [Member] |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  |  |  |  |  |  |  |  | 2,012,167 |
Sales Agent Commission Fee, Percentage |  |  |  |  |  |  |  |  |  | 3.00% |
Proceeds from Issuance of Common Stock | $ |  |  |  |  |  |  |  |  |  | $ 4,900,000 |
Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio |  |  |  |  | 15 |  |  |  |  |  |

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