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Note 6 - Stockholders' Equity- Stock Option Activity (Details) - USD ($)
 3 Months Ended 12 Months Ended
Mar. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Outstanding, number of shares (in shares) 333,648 134,609  
Outstanding, weighted average exercise price (in dollars per share) $ 12.71 $ 28.41  
Outstanding, weighted average remaining contractual term (Year) 9 years 4 months 24 days 8 years 7 months 6 days 8 years 2 months 12 days
Outstanding, aggregate intrinsic value $ 0 $ 58,500 $ 0
Granted, number of shares (in shares) 805,300 200,000  
Granted, weighted average exercise price (in dollars per share) $ 2.48 $ 2.23  
Exercised, number of shares (in shares)   0  
Exercised, weighted average exercise price (in dollars per share)   $ 0  
Forfeited or expired, number of shares (in shares)   (961)  
Forfeited or expired, weighted average exercise price (in dollars per share)   $ 30.17  
Outstanding, number of shares (in shares) 1,138,948 333,648 134,609
Outstanding, weighted average exercise price (in dollars per share) $ 5.48 $ 12.71 $ 28.41
Exercisable, number of shares (in shares) 117,905 117,905  
Exercisable, weighted average exercise price (in dollars per share) $ 30.67 $ 30.67  
Exercisable, weighted average remaining contractual term (Year) 6 years 9 months 18 days 7 years 1 month 6 days  
Exercisable, aggregate intrinsic value $ 0 $ 0