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Note 7 - Stock-Based Compensation Expense - Schedule of Stock-Based Compensation Expense (Details) - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2025 | Mar. 31, 2024 | Dec. 31, 2024 | Dec. 31, 2023
Total stock-based compensation expense |  |  | $ 528,644 | $ 1,074,957
Share-Based Payment Arrangement, Option [Member] |  |  |  |
Total stock-based compensation expense | $ 292,744 | $ 103,569 | 474,477 | 855,124
Share-Based Payment Arrangement, Option [Member] | Research and Development Expense [Member] |  |  |  |
Total stock-based compensation expense |  |  | 222,202 | 291,094
Share-Based Payment Arrangement, Option [Member] | General and Administrative Expense [Member] |  |  |  |
Total stock-based compensation expense |  |  | 252,275 | 564,030
Restricted Stock [Member] | General and Administrative Expense [Member] |  |  |  |
Total stock-based compensation expense |  |  | $ 54,167 | $ 219,833

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section S45 -Paragraph 1 -Publisher FASB -URI https://asc.fasb.org/1943274/2147479983/718-10-S45-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479830/718-10-S99-1 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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