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Note 5 - Stockholders' Equity - 10Q (Tables) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2025 | Dec. 31, 2024
Notes Tables |  |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Number of Shares |  |  | Weighted- Average Exercise Price |  |  | Weighted- Average Remaining Contractual Term (yrs) |  |  | Aggregate Intrinsic Value |
Outstanding at December 31, 2024 |  |  | 333,648 |  |  | $ | 12.71 |  |  |  | 8.6 |  |  | $ | 58,500 |
Stock options granted |  |  | 805,300 |  |  |  | 2.48 |  |  |  |  |  |  |  |  |
Outstanding at March 31, 2025 |  |  | 1,138,948 |  |  | $ | 5.48 |  |  |  | 9.4 |  |  | $ | - |
Exercisable at March 31, 2025 |  |  | 117,905 |  |  | $ | 30.67 |  |  |  | 6.8 |  |  | $ | - |
|  | Number of Shares |  |  | Weighted- Average Exercise Price |  |  | Weighted- Average Remaining Contractual Term (yrs) |  |  | Aggregate Intrinsic Value |
Outstanding at December 31, 2023 |  |  | 134,609 |  |  | $ | 28.41 |  |  |  | 8.2 |  |  | $ | -0- |
Granted |  |  | 200,000 |  |  |  | 2.23 |  |  |  |  |  |  |  |  |
Exercised |  |  | - |  |  |  | - |  |  |  |  |  |  |  |  |
Forfeited or expired |  |  | (961 | ) |  |  | 30.17 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2024 |  |  | 333,648 |  |  | $ | 12.71 |  |  |  | 8.6 |  |  | $ | 58,500 |
Exercisable at December 31, 2024 |  |  | 117,905 |  |  | $ | 30.67 |  |  |  | 7.1 |  |  | $ | - |
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] |
|  | Common Warrants |  |  |  |  |  |  |  |  |
|  | Number of Shares |  |  | Weighted- Average Exercise Price |  |  | Weighted- Average Remaining Contractual Term (yrs) |  |  | Pre-Funded Warrants Number of Shares |  |  | Total Warrants |
Outstanding at December 31, 2024 |  |  | 6,617,747 |  |  | $ | 5.13 |  |  |  | 4.6 |  |  |  | - |  |  |  | 6,617,747 |
Warrants issued |  |  | 3,435,115 |  |  |  | 1.31 |  |  |  |  |  |  |  | 2,085,115 |  |  |  | 5,520,230 |
Outstanding at March 31, 2025 |  |  | 10,052,862 |  |  | $ | 2.61 |  |  |  | 4.8 |  |  |  | - |  |  |  | 12,137,977 |
Issue Date |  | Number of Shares |  |  | Exercise Price |  |  | Expiration |
September 2020 |  |  | 159,781 |  |  | $ | 75.00 |  |  | September 2025 |
September 2021 |  |  | 6,668 |  |  |  | 195.00 |  |  | September 2026 |
May 2024 |  |  | 1,605,688 |  |  |  | 1.31 |  |  | May 2029 |
July 2024 |  |  | 2,170,000 |  |  |  | 1.31 |  |  | January 2030 |
August 2024 |  |  | 2,675,610 |  |  |  | 1.31 |  |  | March 2030 |
March 2025 |  |  | 2,085,115 |  |  |  | 0.0001 |  |  | n/a |
March 2025 |  |  | 3,435,115 |  |  |  | 1.31 |  |  | June 2030 |
Outstanding at March 31, 2025 |  |  | 12,137,977 |  |  |  |  |  |  |  |
|  | Common Warrants |  |  |  |  |  |  |  |  |
|  | Number of Shares |  |  | Weighted- Average Exercise Price |  |  | Weighted- Average Remaining Contractual Term (yrs) |  |  | Pre-Funded Warrants Number of Shares |  |  | Total Warrants |
Outstanding at December 31, 2023 |  |  | 1,596,781 |  |  | $ | 14.58 |  |  |  | 5.0 |  |  |  | - |  |  |  | 2,103,813 |
Issued |  |  | 6,451,298 |  |  |  | 3.45 |  |  |  |  |  |  |  | 1,686,591 |  |  |  | 8,137,889 |
Exercised |  |  | (1,416,998 | )* |  |  | 1.68 |  |  |  |  |  |  |  | (2,193,623 | ) |  |  | (3,610,621 | )
Forfeited/Expired |  |  | (13,334 | ) |  |  | 89.92 |  |  |  |  |  |  |  | - |  |  |  | (13,334 | )
Outstanding at December 31, 2024 |  |  | 6,617,747 |  |  | $ | 5.13 |  |  |  | 4.6 |  |  |  | - |  |  |  | 6,617,747 |
Issue Date |  | Number of Shares |  |  | Exercise Price |  | Expiration
September 2020 |  |  | 159,781 |  |  | $ | 75.00 |  | September 2025
September 2021 |  |  | 6,668 |  |  |  | 195.00 |  | September 2026
May 2024 |  |  | 1,605,688 |  |  |  | 1.68 |  | May 2029
July 2024 |  |  | 2,170,000 |  |  |  | 2.13 |  | January 2030
August 2024 |  |  | 2,675,610 |  |  |  | 5.00 |  | August 2029
Outstanding at December 31, 2024 |  |  | 6,617,747 |  |  |  |  |  |

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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of warrants or rights issued. Warrants and rights outstanding are derivative securities that give the holder the right to purchase securities (usually equity) from the issuer at a specific price within a certain time frame. Warrants are often included in a new debt issue to entice investors by a higher return potential. The main difference between warrants and call options is that warrants are issued and guaranteed by the company, whereas options are exchange instruments and are not issued by the company. Also, the lifetime of a warrant is often measured in years, while the lifetime of a typical option is measured in months. Disclose the title of issue of securities called for by warrants and rights outstanding, the aggregate amount of securities called for by warrants and rights outstanding, the date from which the warrants or rights are exercisable, and the price at which the warrant or right is exercisable. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 505 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 3 -Publisher FASB -URI https://asc.fasb.org/1943274/2147481112/505-10-50-3 + Details
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