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Income Taxes - Deferred tax assets (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2018 | Dec. 31, 2017
Deferred tax assets: |  |
Federal and state net operating loss carryforwards | $ 11,946 | $ 6,176
Research and development tax credits | 3,393 | 1,283
Charitable contribution carryforwards | 165 | 153
Accruals | 290 | 135
Other | 23 | 4
Gross deferred tax assets | 15,817 | 7,751
Less: valuation allowance | (15,525) | (7,491)
Total deferred tax assets | 292 | 260
Deferred tax liabilities: |  |
Depreciation and amortization | (292) | (260)
Gross deferred tax liabilities | (292) | $ (260)
Increase in valuation allowance | 8,000 |
Federal net operating loss carryforwards | 43,500 |
State net operating loss carryforwards | 43,000 |
Federal and state net operating loss carryforwards that do not expire | 20,800 |
Federal research and development tax credit carryforwards | 2,500 |
State research and development tax credit carryforwards | 1,100 |
Unrecognized income tax benefits | $ 0 |

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