<SEC-DOCUMENT>0001104659-21-134475.txt : 20211104
<SEC-HEADER>0001104659-21-134475.hdr.sgml : 20211104
<ACCEPTANCE-DATETIME>20211104165921
ACCESSION NUMBER:		0001104659-21-134475
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20211104
DATE AS OF CHANGE:		20211104
EFFECTIVENESS DATE:		20211104

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NextCure, Inc.
		CENTRAL INDEX KEY:			0001661059
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				475231247
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-260776
		FILM NUMBER:		211380931

	BUSINESS ADDRESS:	
		STREET 1:		9000 VIRGINIA MANOR ROAD, SUITE 200
		CITY:			BELTSVILLE
		STATE:			MD
		ZIP:			20705
		BUSINESS PHONE:		240-399-4900

	MAIL ADDRESS:	
		STREET 1:		9000 VIRGINIA MANOR ROAD, SUITE 200
		CITY:			BELTSVILLE
		STATE:			MD
		ZIP:			20705
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>tm2131564d2_s8.htm
<DESCRIPTION>FORM S-8
<TEXT>
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     <TITLE></TITLE>
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<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="text-align: center; margin-top: 0; margin-bottom: 0"><B>As filed with the Securities and Exchange Commission
on November 4, 2021</B></P>

<P STYLE="margin: 0"></P>



<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0">&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B></B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, DC 20549</B></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 5pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT UNDER THE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES ACT OF 1933</B></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 5pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>NextCure, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact name of registrant as specified in its charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: bottom; padding: 0.25pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt; font-size: 10pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom; padding: 0.25pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>47-5231247</B></FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(State or other jurisdiction of<BR>
incorporation or organization)</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt; font-size: 10pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(I.R.S. Employer<BR>
    Identification No.)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt; font-size: 10pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt; font-size: 10pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD COLSPAN="5" STYLE="vertical-align: top; padding: 0.25pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>9000 Virginia Manor Road, Suite 200<BR>
Beltsville, Maryland 20705</B></FONT></TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
  <TR>
    <TD COLSPAN="5" STYLE="vertical-align: top; padding: 0.25pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(Address, including zip code, of <BR>
principal executive offices)</FONT></TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="width: 23%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 46%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 28%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>NEXTCURE, INC. 2019 EMPLOYEE STOCK PURCHASE
PLAN</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Full title of the plan)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Michael Richman</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Chief Executive Officer</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>NextCure, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>9000 Virginia Manor Road, Suite 200</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Beltsville, Maryland 20705</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(240) 399-4900</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, address, including zip code, and telephone
number, including area code, of agent for service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>With Copies to:</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: top; width: 50%; padding: 0.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Asher M. Rubin<BR>
    </B>Sidley Austin LLP<BR>
    2850 Quarry Lake Dr., Suite 301</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Baltimore, MD 21209</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(312) 853-7000</P></TD>
    <TD STYLE="vertical-align: bottom; width: 1%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 49%; padding: 0.25pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Steven P. Cobourn<BR>
</B>Chief Financial Officer<BR>
NextCure, Inc.<BR>
9000 Virginia Manor Road, Suite 200<BR>
Beltsville, Maryland 20705<BR>
(240) 399-4900</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging
growth company&#8221; in Rule 12b-2 of the Exchange Act (Check one):</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 16%; padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Large accelerated filer</FONT></TD>
    <TD STYLE="width: 45%; padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD>
    <TD STYLE="width: 20%; padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Accelerated filer</FONT></TD>
    <TD STYLE="padding: 0.25pt; font-size: 10pt; width: 19%"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Non-accelerated filer</FONT></TD>
    <TD STYLE="padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">x</FONT></TD>
    <TD STYLE="padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Smaller reporting company</FONT></TD>
    <TD STYLE="padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">x</FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="width: 16%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 45%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 20%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 19%; padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Emerging growth company</FONT></TD>
    <TD STYLE="padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">x</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section 7(a)(2)(B) of Securities Act. <FONT STYLE="font-family: Wingdings">o</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B></B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt"><FONT STYLE="font-size: 0pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt"><FONT STYLE="font-size: 0pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt"><FONT STYLE="font-size: 0pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt"><FONT STYLE="font-size: 0pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 0pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt"><FONT STYLE="font-size: 0pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt"><FONT STYLE="font-size: 0pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt"><FONT STYLE="font-size: 0pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt"><FONT STYLE="font-size: 0pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt"><FONT STYLE="font-size: 0pt">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title of Each Class of<BR>
Securities to be Registered</B></FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Amount<BR>
to be<BR>
Registered(1)</B></FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Proposed<BR>
Maximum<BR>
Offering Price<BR>
Per Share</B></FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Proposed<BR>
Maximum<BR>
Aggregate Offering<BR>
Price</B></FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Amount of<BR>
Registration Fee</B></FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
    <TD STYLE="vertical-align: top; width: 37%; border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt 10.1pt; font-size: 10pt; text-indent: -10.1pt"><FONT STYLE="font-size: 10pt">Common Stock, $0.001 par value per share</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 2%; border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 14%; border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">550,680</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 2%; border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%; border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt; vertical-align: bottom; width: 12%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">8.22</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 3%; border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 1%; border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt; vertical-align: bottom; width: 12%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">4,526,589.60</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 3%; border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 1%; border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt; vertical-align: bottom; width: 11%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">419.61</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 1%; border-bottom: black 2.25pt double; padding: 0.25pt 0.25pt 1.1pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B></B>&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>Consists for shares available for issuance under the NextCure, Inc. 2019 Employee Stock Purchase Plan (the &#8220;ESPP&#8221;). The
number of shares of Common Stock, $0.001 par value per share (the &#8220;Common Stock&#8221;), available for issuance under the ESPP is
subject to an automatic annual increase on January&nbsp;1st of each year, commencing on January&nbsp;1, 2020 and continuing until the
expiration of the ESPP, in an amount equal to the least of (i)&nbsp;one percent (1%) of the total number of shares of Common Stock outstanding
on December&nbsp;31st of the preceding calendar year, (ii) four hundred eighty thousand (480,000) shares of Common Stock (subject to the
capitalization adjustment provisions included in the ESPP) and (iii)&nbsp;a number of shares of Common Stock determined by the administrator
of the ESPP (the &#8220;ESPP Evergreen Provision&#8221;). Accordingly, the number of shares of Common Stock available for issuance under
the ESPP was increased by 550,680 shares, which is equal to the sum of (i) 1% of the total number of shares of Common Stock outstanding
as of December&nbsp;31, 2019 and (ii) 1% of the total number of shares of Common Stock outstanding as of December&nbsp;31, 2020. This
Registration Statement registers the 550,680 additional shares of Common Stock available for issuance under the ESPP as of January&nbsp;1,
2021 as a result of 2020 and 2021 increases due to the ESPP Evergreen Provision. In accordance with Rule 416(a) under the Securities Act
of 1933, as amended (the &#8220;Securities Act&#8221;), this registration statement shall also cover any additional shares of the registrant&#8217;s
common stock that become issuable under the ESPP by reason of any stock dividend, stock split, recapitalization or similar transaction
effected without the registrant&#8217;s receipt of consideration which would increase the number of outstanding shares of common stock.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(2)</TD><TD>Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h) and Rule 457(c) promulgated
under the Securities Act. The offering price per share and aggregate offering price are based on the average of the high and the low price
of the registrant&#8217;s common stock as reported on The Nasdaq Global Select Market on October 29, 2021.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXPLANATORY NOTE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="background-color: white">This Registration Statement on
Form S-8 (this &#8220;Registration Statement&#8221;) is being filed by NextCure, Inc., a Delaware corporation (the &#8220;Registrant&#8221;),
relating to </FONT>550,680 s<FONT STYLE="background-color: white">hares of its Common Stock, par value $0.001 per share (the &#8220;Common
Stock&#8221;), issuable to eligible employees under the </FONT>NextCure, Inc. 2019 Employee Stock Purchase Plan<FONT STYLE="background-color: white">.
The Registrant filed with the Securities and Exchange Commission (the &#8220;Commission&#8221;) on May 13, 2019 a Registration Statement
on Form S-8 (Registration No. <A HREF="https://www.sec.gov/Archives/edgar/data/0001661059/000110465919029017/a19-3387_11s8.htm" STYLE="-sec-extract: exhibit">333-231438</A></FONT>) (the &#8220;Prior Registration Statement&#8221;). <FONT STYLE="background-color: white">This
Registration Statement relates to securities of the same class as those to which the Prior Registration Statement relates and is submitted
in accordance with General Instruction E of Form S-8 regarding the Registration of Additional Securities. Pursuant to General Instruction
E of Form S-8, the contents of the Prior Registration Statement are incorporated herein by reference and made part of this Registration
Statement, except as amended hereby.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 0.5in"><B>Item 3.</B></TD><TD><B>Incorporation of Documents by Reference.</B></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Registrant hereby incorporates by reference
in this Registration Statement the following documents and information previously filed with the Commission:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; border-left-width: 0in; border-left-color: Black"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(a)</TD><TD STYLE="text-align: justify"><FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1661059/000155837021002384/nxtc-20201231x10k.htm" STYLE="-sec-extract: exhibit">the Registrant&#8217;s Annual Report on Form 10-K for the year ended December 31, 2020, filed with the Commission on March 4, 2021</A> and as amended on <A HREF="http://www.sec.gov/Archives/edgar/data/1661059/000110465921054980/tm2113858d1_10ka.htm" STYLE="-sec-extract: exhibit">April 26, 2021;</A></FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; border-left-width: 0in; border-left-color: Black"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(b)</TD><TD STYLE="text-align: justify">the Registrant&#8217;s Quarterly Reports
on Form 10-Q for the quarters ended March 31, 2021, June 30, 2021 and September 30, 2021, filed with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1661059/000155837021006266/nxtc-20210331x10q.htm" STYLE="-sec-extract: exhibit">May
6, 2021</A>, <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/1661059/000155837021010578/nxtc-20210630x10q.htm" STYLE="-sec-extract: exhibit">August
5, 2021</A> and November 4, 2021, respectively;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; border-left-width: 0in; border-left-color: Black"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(c)</TD><TD STYLE="text-align: justify">the Registrant&#8217;s Current Reports on Form 8-K, filed with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/0001661059/000110465921027570/tm217883d1_8k.htm" STYLE="-sec-extract: exhibit">February 24, 2021</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/0001661059/000110465921062513/tm2115384d1_8k.htm" STYLE="-sec-extract: exhibit">May 6, 2021</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/0001661059/000110465921085703/tm2120703d1_8k.htm" STYLE="-sec-extract: exhibit">June 25, 2021</A>, <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/1661059/000110465921119299/tm2128375d1_8k.htm" STYLE="-sec-extract: exhibit">September 24, 2021</A> and <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/1661059/000110465921122499/tm2129158d1_8k.htm" STYLE="-sec-extract: exhibit">October 4, 2021</A>; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; border-left-width: 0in; border-left-color: Black"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(d)</TD><TD STYLE="text-align: justify"><A HREF="http://www.sec.gov/Archives/edgar/data/1661059/000110465919027670/a19-3387_98a12b.htm" STYLE="-sec-extract: exhibit"><FONT>The description of the Registrant&#8217;s Common Stock contained in the Registrant&#8217;s Registration Statement on&nbsp;Form&nbsp;8-A&nbsp;(File No.&nbsp;001-38905), filed with the Commission on May&nbsp;8, 2019 under Section&nbsp;12(b)&nbsp;of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), including any amendments or reports filed for the purpose of updating such description</FONT>.</A></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">All documents subsequently filed by the
Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment to this
Registration Statement which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining
unsold, shall be deemed to be incorporated by reference into this Registration Statement and will be part hereof from the date of filing
of such documents; provided, however, that documents, reports and definitive proxy or information statements, or portions thereof, which
are furnished and not filed in accordance with the rules of the Commission shall not be deemed incorporated by reference into this Registration
Statement.</FONT><BR>
<BR>
<FONT STYLE="font-size: 10pt">Any statement contained herein or in a document, all or a portion of which is incorporated or deemed to
be incorporated by reference herein, shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent
that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference
herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified
or amended, to constitute a part of this Registration Statement.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 7%"><B>Item 8.</B></TD><TD STYLE="width: 93%"><B>Exhibits.</B></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: top; padding-top: 1.75pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify; width: 10%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Exhibit No.</B></FONT></TD>
    <TD STYLE="padding-top: 0.25pt; padding-right: 1.25pt; padding-left: 1.25pt; width: 2%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 1.75pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify; width: 88%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Description</B></FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding-top: 2pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="http://www.sec.gov/Archives/edgar/data/1661059/000104746919003060/a2238817zex-3_1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.1*</FONT></A></TD>
    <TD STYLE="padding-top: 0.25pt; padding-right: 1.25pt; padding-left: 1.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 2pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="http://www.sec.gov/Archives/edgar/data/1661059/000104746919003060/a2238817zex-3_1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Amended
    and Restated Certificate of Incorporation of NextCure, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant&rsquo;s Current
    Report on Form 8-K filed with the Commission on May 13, 2019)</FONT></A></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding-top: 2pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="http://www.sec.gov/Archives/edgar/data/1661059/000104746919003060/a2238817zex-3_2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.2*</FONT></A></TD>
    <TD STYLE="padding-top: 0.25pt; padding-right: 1.25pt; padding-left: 1.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 2pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="http://www.sec.gov/Archives/edgar/data/1661059/000104746919003060/a2238817zex-3_2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Amended
    and Restated Bylaws of NextCure, Inc. (incorporated by reference to Exhibit 3.2 to the Registrant&rsquo;s Current Report on Form
    8-K filed with the Commission on May 13, 2019)</FONT></A></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding-top: 2pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="http://www.sec.gov/Archives/edgar/data/1661059/000104746919002652/a2238596zex-10_12.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.3*</FONT></A></TD>
    <TD STYLE="padding-top: 0.25pt; padding-right: 1.25pt; padding-left: 1.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 2pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="http://www.sec.gov/Archives/edgar/data/1661059/000104746919002652/a2238596zex-10_12.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">NextCure,
    Inc. 2019 Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.12 to Amendment No. 1 to the Registrant&rsquo;s Registration
    Statement on Form S-1 filed with the Commission on April 29, 2019)</FONT></A></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding-top: 1.75pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="tm2131564d2_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">5.1**</FONT></A></TD>
    <TD STYLE="padding-top: 0.25pt; padding-right: 1.25pt; padding-left: 1.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 1.75pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="tm2131564d2_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Opinion
    of Sidley Austin LLP</FONT></A></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding-top: 1.75pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="tm2131564d2_ex23-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">23.1**</FONT></A></TD>
    <TD STYLE="padding-top: 0.25pt; padding-right: 1.25pt; padding-left: 1.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 1.75pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="tm2131564d2_ex23-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Consent
    of Independent Registered Public Accounting Firm</FONT></A></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding-top: 1.75pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="tm2131564d2_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">23.2**</FONT></A></TD>
    <TD STYLE="padding-top: 0.25pt; padding-right: 1.25pt; padding-left: 1.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 1.75pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="tm2131564d2_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Consent
    of Sidley Austin LLP (included in Exhibit 5.1)</FONT></A></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding-top: 1.75pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="#B2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">24.1**</FONT></A></TD>
    <TD STYLE="padding-top: 0.25pt; padding-right: 1.25pt; padding-left: 1.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 1.75pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><A HREF="#B2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Power
    of Attorney (contained in signature page to this Registration Statement)</FONT></A></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding-top: 1.75pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-top: 0.25pt; padding-right: 1.25pt; padding-left: 1.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 1.75pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding-top: 2pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">* Previously filed with the Commission and incorporated herein by reference.</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding-top: 1.75pt; padding-right: 1.25pt; padding-left: 1.25pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">** Filed herewith.</FONT></TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="B2"></A>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 22.5pt">Pursuant to the requirements of the Securities
Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized,
in the City of Beltsville, in the State of Maryland, on November 4, 2021.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 22.5pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>NEXTCURE, INC.</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 3%; padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="width: 47%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ Steven P. Cobourn</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Steven P. Cobourn</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Chief Financial Officer </TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="a_001"></A>POWER OF ATTORNEY AND SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">The undersigned officers and
directors of NextCure, Inc., a Delaware corporation (the &#8220;Company&#8221;), hereby constitute and appoint&nbsp;Michael Richman&nbsp;and&nbsp;Steven
P. Cobourn, and each of them, the true and lawful agents and attorneys-in-fact of the undersigned with full power and authority in said
agents and attorneys-in-fact, and each of them, to sign for the undersigned, individually and in each capacity stated below, one or more
Registration Statements on Form S-8 of the Company to be filed with the Securities and Exchange Commission under the Securities Act of
1933, as amended, and any amendment or amendments to each such Registration Statement, relating to securities of the Company acquired
under the NextCure, Inc. 2019 Employee Stock Purchase Plan, and hereby ratify and confirm all acts taken by such agents and attorneys-in-fact,
or either of them, as herein authorized.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="width: 30%; padding: 1pt">&nbsp;</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="padding: 1pt">&nbsp;</TD>
    <TD STYLE="width: 2%; padding: 1pt">&nbsp;</TD>
    <TD STYLE="width: 20%; padding: 1pt">&nbsp;</TD>
    </TR>
  <TR>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B><U>Name</U></B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B><U>Title</U></B></FONT></TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B><U>Date</U></B></FONT></TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ Michael Richman</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt 1.75pt 4pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">President, Chief Executive Officer and Director </FONT></TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">November 4, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="border-top: black 1pt solid; padding: 2pt 1.25pt 1.75pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">Michael Richman</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt 0.25pt 4pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">(Principal Executive Officer)</FONT></TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ Steven P. Cobourn</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt 1.75pt 4pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">Chief Financial Officer</FONT></TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">November 4, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="border-top: black 1pt solid; padding: 2pt 1.25pt 1.75pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">Steven P. Cobourn</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt 1.75pt 4pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">(Principal Financial and Accounting Officer)</FONT></TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ David Kabakoff, Ph.D.</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt 1.75pt 4pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">Chair of the Board of Directors</FONT></TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">November 4, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="border-top: black 1pt solid; padding: 2pt 1.25pt 1.75pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">David Kabakoff, Ph.D.</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt 1.75pt 4pt; vertical-align: top">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ John G. Houston, Ph.D.</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt 1.75pt 4pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">November 4, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="border-top: black 1pt solid; padding: 2pt 1.25pt 1.75pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">John G. Houston, Ph.D.</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ Elaine V. Jones, Ph.D.</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt 1.75pt 4pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">November 4, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="border-top: black 1pt solid; padding: 2pt 1.25pt 1.75pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">Elaine V. Jones, Ph.D.</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ Chau Q. Khuong</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt 1.75pt 4pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">November 4, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="border-top: black 1pt solid; padding: 2pt 1.25pt 1.75pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">Chau Q. Khuong</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ Garry A. Nicholson</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt 1.75pt 4pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 1.75pt 1.25pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">November 4, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="border-top: black 1pt solid; padding: 2pt 1.25pt 1.75pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">Garry A. Nicholson </FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 2pt 1.25pt 1.75pt; vertical-align: top; font-size: 10pt; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt; font-size: 10pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-bottom: black 1pt solid; padding: 2pt 1.25pt 1.75pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ Stephen W. Webster</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt; vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="padding: 0.25pt 1.25pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">November 4, 2021</FONT></TD></TR>

<TR>
    <TD STYLE="border-top: black 1pt solid; padding: 2pt 1.25pt 1.75pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">Stephen W. Webster </FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 1.25pt; font-size: 10pt">&nbsp;</TD></TR>
  </TABLE>
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<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>tm2131564d2_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

                           <P STYLE="margin: 0pt">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">Exhibit 5.1</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 10pt; width: 25%; font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><IMG SRC="tm2131564d2_ex5-1img01.jpg" ALT="" STYLE="height: 41px; width: 142px"></FONT></TD>
    <TD STYLE="width: 75%">
    <P STYLE="text-transform: uppercase; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0">Sidley Austin LLP</P>
    <P STYLE="text-transform: uppercase; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0">One South Dearborn Street</P>
    <P STYLE="text-transform: uppercase; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0">Chicago, IL 60603</P>
    <P STYLE="text-transform: uppercase; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0">+1 312 853 7000</P>
    <P STYLE="text-transform: uppercase; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0">+1 312 853 7036 Fax</P></TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
  <TD STYLE="text-align: right; padding-left: 10pt; text-indent: -10pt; width: 25%">&nbsp;</TD>
  <TD STYLE="text-align: right; width: 75%"><P STYLE="text-align: left; margin: 0pt 0; font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">AMERICA
                                            </FONT><FONT STYLE="font-family: Symbol">&middot;</FONT> <FONT STYLE="font-family: Times New Roman, Times, Serif">ASIA
                                            PACIFIC </FONT><FONT STYLE="font-family: Symbol">&middot;</FONT> <FONT STYLE="font-family: Times New Roman, Times, Serif">EUROPE</FONT></P></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">November 4, 2021</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">NextCure, Inc.<BR>
9000 Virginia Manor Road<BR>
Suite 200<BR>
Beltsville, MD 20705</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1in"></TD><TD STYLE="width: 0.5in">Re:</TD><TD><U>550,680 Shares of Common Stock, $0.001 par value per share</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Ladies and Gentlemen:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">We refer to the Registration Statement on Form S-8
(the &#8220;<U>Registration Statement</U>&#8221;) being filed by NextCure, Inc., a Delaware corporation (the &#8220;<U>Company</U>&#8221;),
with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the &#8220;<U>Securities Act</U>&#8221;), relating
to the registration of 550,680 shares of Common Stock, $0.001 par value per share (the &#8220;<U>Registered Shares</U>&#8221;), of the
Company which may be issued under the NextCure, Inc. 2019 Employee Stock Purchase Plan (the &#8220;<U>Plan</U>&#8221;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">This opinion letter is being delivered in accordance
with the requirements of Item 601(b)(5) of Regulation S-K under the Securities Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">We have examined the Registration Statement, the
Company&#8217;s Amended and Restated Certificate of Incorporation, the Company&#8217;s Amended and Restated Bylaws, the Plan and the resolutions
adopted by the board of directors of the Company relating to the Registration Statement and the Plan and the resolutions adopted by the
stockholders of the Company relating to the Plan. We have also examined originals, or copies of originals certified to our satisfaction,
of such agreements, documents, certificates and statements of the Company and other corporate documents and instruments, and have examined
such questions of law, as we have considered relevant and necessary as a basis for this opinion letter. We have assumed the authenticity
of all documents submitted to us as originals, the genuineness of all signatures, the legal capacity of all persons and the conformity
with the original documents of any copies thereof submitted to us for examination. As to facts relevant to the opinions expressed herein,
we have relied without independent investigation or verification upon, and assumed the accuracy and completeness of, certificates, letters
and oral and written statements and representations of public officials and officers and other representatives of the Company.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">Based on the foregoing, we are of the opinion
that each Registered Share that is newly issued pursuant to the Plan will be validly issued, fully paid and non-assessable when: (i)
the Registration Statement, as finally amended, shall have become effective under the Securities Act; (ii) such Registered Share
shall have been duly issued and delivered in accordance with the Plan; and (iii) certificates representing such Registered Share
shall have been duly executed, countersigned and registered and duly delivered to the person entitled thereto against payment of the
agreed consideration therefor (in an amount not less than the par value thereof) or, if any Registered Share is to be issued in
uncertificated form, the Company&#8217;s books shall reflect the issuance of such Registered Share to the person entitled thereto
against payment of the agreed consideration therefor (in an amount not less than the par value thereof), all in accordance with the
Plan.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">Sidley Austin LLP is a limited liability partnership practicing in
affiliation with other Sidley Austin partnerships.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><IMG SRC="tm2131564d2_ex5-1img02.jpg" ALT="">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">NextCure, Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">November 4, 2021</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Page
</FONT>2</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">This opinion letter is limited to the General Corporation
Law of the State of Delaware. We express no opinion as to the laws, rules or regulations of any other jurisdiction, including, without
limitation, the federal laws of the United States of America or any state securities or blue sky laws.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">We hereby consent to the filing of this opinion letter
as an Exhibit to the Registration Statement and to all references to our Firm included in or made a part of the Registration Statement.
In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the
Securities Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
  <TD STYLE="padding-left: 10pt; text-indent: -10pt; width: 50%">&nbsp;</TD>
  <TD STYLE="padding-left: 10pt; text-indent: -10pt; width: 50%">Very truly yours,</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

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<TR STYLE="vertical-align: top">
  <TD STYLE="padding-left: 10pt; text-indent: -10pt; width: 50%">&nbsp;</TD>
  <TD STYLE="padding-left: 10pt; text-indent: -10pt; width: 50%">/s/ Sidley Austin LLP</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>tm2131564d2_ex5-1img01.jpg
<DESCRIPTION>GRAPHIC
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<TEXT>
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</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 23.1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Consent of Independent Registered Public Accounting
Firm</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="background-color: white">We consent
to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the NextCure, Inc. 2019 Employee Stock Purchase
Plan of our report dated March 4, 2021, with respect to the financial statements of NextCure, Inc. included in its Annual Report (Form
10-K) for the year ended December 31, 2020, filed with the Securities and Exchange Commission. </FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">/s/ Ernst &amp; Young LLP</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Baltimore, MD</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">November 4, 2021</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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