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Income Taxes - Deferred tax assets (Details) - USD ($) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2022 | Dec. 31, 2021
Deferred tax assets: |  |
Federal and state net operating loss carryforwards | $ 49,789,000 | $ 44,451,000
Research and development tax credits | 11,395,000 | 8,862,000
Capitalized R&D Costs | 12,424,000 |
Operating lease liabilities | 1,960,000 |
Share-based compensation | 4,389,000 | 3,184,000
Accruals and other | 1,305,000 | 1,291,000
Gross deferred tax assets | 81,262,000 | 57,788,000
Less: valuation allowance | (79,724,000) | (57,705,000)
Total deferred tax assets | 1,538,000 | 83,000
Deferred tax liabilities: |  |
Depreciation and amortization |  | (83,000)
Operating lease assets | (1,538,000) |
Gross deferred tax liabilities | (1,538,000) | $ (83,000)
Increase in valuation allowance | 21,900,000 |
Federal net operating loss carryforwards | 180,200,000 |
State net operating loss carryforwards | 183,100,000 |
Federal net operating loss carryforwards that do not expire | 157,500,000 |
Federal research and development tax credit carryforwards | 11,300,000 |
State research and development tax credit carryforwards | 100,000 |
Unrecognized income tax benefits | $ 0 |

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