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STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021
Cash flows from operating activities: |  |
Net loss | $ (74,733) | $ (69,389)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 4,124 | 4,177
Amortization of premiums and discounts on marketable securities | 3,047 | 3,019
Stock-based compensation | 9,508 | 10,288
Noncash operating lease expense | 356 |
Loss on disposal of property and equipment | 87 |
Changes in operating assets and liabilities: |  |
Prepaid expenses and other assets | 2,038 | (4,928)
Accounts payable | 2,328 | (1,959)
Accrued liabilities and other liabilities | (641) | (178)
Other long-term liabilities |  | 1,687
Net cash used in operating activities | (53,886) | (57,283)
Cash flows from investing activities: |  |
Sales and maturities of marketable securities | 104,739 | 195,438
Purchases of marketable securities | (34,644) | (156,477)
Purchases of property and equipment | (2,116) | (2,360)
Net cash provided by investing activities | 67,979 | 36,601
Cash flows from financing activities: |  |
Proceeds from exercise of stock options | 66 | 208
Proceeds from shares issued under ESPP | 134 |
Payments of the term loan |  | (3,473)
Net cash provided by (used in) financing activities | 200 | (3,265)
Net increase (decrease) in cash and cash equivalents | 14,293 | (23,947)
Cash and cash equivalents - beginning of period | 12,337 | 36,284
Cash and cash equivalents - end of period | 26,630 | 12,337
Supplemental disclosures of cash flow information: |  |
Cash paid for interest | 90 | $ 162
Supplemental disclosures of noncash investing and financing activities: |  |
Right-o-use assets obtained in exchange for operating lease liabilities | 6,047 |
Recognition of initial lease liabilities | $ 7,549 |

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