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STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Cash flows from operating activities:    
Net loss $ (74,733) $ (69,389)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 4,124 4,177
Amortization of premiums and discounts on marketable securities 3,047 3,019
Stock-based compensation 9,508 10,288
Noncash operating lease expense 356  
Loss on disposal of property and equipment 87  
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 2,038 (4,928)
Accounts payable 2,328 (1,959)
Accrued liabilities and other liabilities (641) (178)
Other long-term liabilities   1,687
Net cash used in operating activities (53,886) (57,283)
Cash flows from investing activities:    
Sales and maturities of marketable securities 104,739 195,438
Purchases of marketable securities (34,644) (156,477)
Purchases of property and equipment (2,116) (2,360)
Net cash provided by investing activities 67,979 36,601
Cash flows from financing activities:    
Proceeds from exercise of stock options 66 208
Proceeds from shares issued under ESPP 134  
Payments of the term loan   (3,473)
Net cash provided by (used in) financing activities 200 (3,265)
Net increase (decrease) in cash and cash equivalents 14,293 (23,947)
Cash and cash equivalents - beginning of period 12,337 36,284
Cash and cash equivalents - end of period 26,630 12,337
Supplemental disclosures of cash flow information:    
Cash paid for interest 90 $ 162
Supplemental disclosures of noncash investing and financing activities:    
Right-o-use assets obtained in exchange for operating lease liabilities 6,047  
Recognition of initial lease liabilities $ 7,549