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STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Cash flows from operating activities:    
Net loss $ (62,723) $ (74,733)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 3,684 4,124
Amortization of premiums and discounts on marketable securities (756) 3,047
Stock-based compensation 8,188 9,508
Noncash operating lease expense 573 356
Loss on disposal of property and equipment   87
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 1,074 2,038
Accounts payable (1,940) 2,328
Accrued liabilities and other liabilities (304) (641)
Lease liabilities (656)  
Other long-term liabilities (114)  
Net cash used in operating activities (52,974) (53,886)
Cash flows from investing activities:    
Sales and maturities of marketable securities 113,597 104,739
Purchases of marketable securities (73,505) (34,644)
Purchases of property and equipment (820) (2,116)
Net cash provided by investing activities 39,272 67,979
Cash flows from financing activities:    
Proceeds from exercise of stock options 5 66
Proceeds from shares issued under ESPP 149 134
Net cash provided by financing activities 154 200
Net (decrease) increase in cash and cash equivalents (13,548) 14,293
Cash and cash equivalents - beginning of period 26,630 12,337
Cash and cash equivalents - end of period 13,082 26,630
Supplemental disclosures of cash flow information:    
Cash paid for interest $ 81 90
Supplemental disclosures of noncash investing and financing activities:    
Right-of-use assets obtained in exchange for operating lease liabilities   6,047
Recognition of initial lease liabilities   $ 7,549