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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2015
Income Tax Disclosure [Abstract] |
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] | Income tax expense consists of:
|  | Current |  | Deferred |  | Total |
Year ended December 31, 2015: |  |  |  |  |  |  |  |  |  |
U.S. federal |  | $ | - |  | $ | - |  | $ | - |
State and local |  |  | 200 |  |  |  |  |  | 200 |
|  | $ | 200 |  | $ | - |  | $ | 200 |
Year ended December 31, 2014: |  |  |  |  |  |  |  |  |  |
U.S. federal |  | $ | - |  | $ | - |  | $ | - |
State and local |  |  | 200 |  |  | - |  |  | 200 |
|  | $ | 200 |  | $ | - |  | $ | 200 |
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] | Income tax expense was $200 for each of the years ended December 31, 2015 and 2014 and differed from the amounts computed by applying the U.S. federal income tax rate of 34% to pretax income from continuing operations as a result of the following:
|  | December 31, |
|  | 2015 |  | 2014 |
Computed "expected" tax expense (benefit) |  | $ | (6,190,781) |  | $ | (6,926,642) |
Increase (reduction) in income taxes resulting from: |  |  |  |  |  |  |
Change in valuation allowance |  |  | 6,691,992 |  |  | 7,748,579 |
Adjustment of tax attributes due to change in ownership |  |  | - |  |  | (127,572) |
State and local income taxes, net of federal income |  |  |  |  |  |  |
tax benefit |  |  | 132 |  |  | 132 |
Stock expense |  |  | 102,221 |  |  | 45,097 |
Research and development tax credits |  |  | (452,609) |  |  | (743,186) |
Orphan drug tax credit |  |  | (155,452) |  |  | - |
Other, net |  |  | 4,697 |  |  | 3,792 |
|  | $ | 200 |  | $ | 200 |
Schedule of Deferred Tax Assets and Liabilities [Table Text Block] | The tax effects of temporary differences that give rise to significant portions of the deferred tax assets and deferred tax liabilities at December 31, 2015 and 2014 are presented below.
|  | December 31, |
|  | 2015 |  | 2014 |
Deferred tax assets: |  |  |  |  |  |  |
Stock-based compensation |  | $ | 1,713,608 |  | $ | 1,851,668 |
Net operating loss carryforwards |  |  | 23,677,332 |  |  | 17,479,654 |
Employee benefits |  |  | 59,472 |  |  | 41,568 |
Research and development tax credits |  |  | 2,052,662 |  |  | 1,419,165 |
Orphan drug tax credits |  |  | 485,789 |  |  | - |
Other deductible tempory differences |  |  | 215,638 |  |  | 97,656 |
Total gross deferred tax assets |  |  | 28,204,501 |  |  | 20,889,711 |
Less valuation allowance |  |  | (28,200,857) |  |  | (20,886,811) |
Net deferred tax assets |  |  | 3,644 |  |  | 2,900 |
Deferred tax liabilities: |  |  |  |  |  |  |
Plant and equipment |  |  | (3,644) |  |  | (2,900) |
Total gross deferred tax liabilities |  |  | (3,644) |  |  | (2,900) |
Net deferred tax liabilities |  | $ | - |  | $ | - |
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] | A reconciliation of the beginning and ending amount of total unrecognized tax contingencies, excluding interest and penalties, for the years ended December 31, 2015 and 2014 are as follows:
|  |  | December 31 |
|  |  | 2015 |  |  | 2014 |
Balance, beginning of year |  | $ | - |  | $ | - |
Balance, end of year |  | $ | - |  | $ | - |

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- Definition Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 9 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32639-109319 + Details
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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32537-109319 + Details
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