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Income Taxes (Details Textual) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014
Income Taxes [Line Items] |  |
Income Tax Expense (Benefit) | $ 200 | $ 200
Operating Loss Carryforwards | 59,900,000 |
Tax Credit Carryforward, Amount | 1,400,000 |
Deferred Tax Assets, Valuation Allowance | 28,200,857 | 20,886,811
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount | 7,300,000 | $ 9,200,000
Operating Loss Carry forwards Limitations On Use Amount | 1,100,000 |
Operating Loss Carry forwards Preownership Change Amount | 20,200,000 |
Operating Loss Forgive Pre ownership Change Amount | 5,500,000 |
Tax Credit Carryforward Preownership Change Amount | 1,200,000 |
Employee Service Share-based Compensation, Tax Benefit Realized from Exercise of Stock Options | 568,000 |
Orphan Drug Credit [Member] |  |
Income Taxes [Line Items] |  |
Tax Credit Carryforward, Amount | $ 486,000 |
U.S. Federal [Member] |  |
Income Taxes [Line Items] |  |
Operating Loss Carry forwards Expiration Date1 | Approximately $10.2 million of the NOLs will begin to expire in 2023 with the balance expiring from 2024 through 2035 |
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent | 34.00% |
U.S. Federal [Member] | Research and Development Expense [Member] |  |
Income Taxes [Line Items] |  |
Tax Credit Carryforward, Description | expire in 2033 through 2035 |
State And Local [Member] |  |
Income Taxes [Line Items] |  |
Operating Loss Carryforwards | $ 65,900,000 |
Operating Loss Carry forwards Expiration Date1 | Approximately $12.4 million of the Company's state NOLs expire in 2018 with the remaining balance expiring from 2019 through 2030 |
State And Local [Member] | Research and Development Expense [Member] |  |
Income Taxes [Line Items] |  |
Tax Credit Carryforward, Amount | $ 689,000 |
Tax Credit Carryforward, Description | expire in 2023 through 2029 |

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- Definition Amount of pre-change credit carryforwards as a result of this ownership change, before tax effects, available to reduce future taxable income under enacted tax laws. + References No definition available. + Details
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- Definition Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32537-109319 + Details
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