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Income Taxes (Details 1) - USD ($)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Income Taxes [Line Items]    
Computed "expected" tax expense (benefit) $ (6,190,781) $ (6,926,642)
Increase (reduction) in income taxes resulting from:    
Change in valuation allowance 6,691,992 7,748,579
Adjustment of tax attributes due to change in ownership 0 (127,572)
State and local income taxes, net of federal income tax benefit 132 132
Stock expense 102,221 45,097
Research and development tax credits (452,609) (743,186)
Orphan drug tax credit (155,452) 0
Other, net 4,697 3,792
Income Tax Expense (Benefit) $ 200 $ 200