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Income Taxes (Details Textual) - USD ($)
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Income Taxes [Line Items]    
Income Tax Expense (Benefit) $ 200 $ 200
Operating Loss Carryforwards 59,900,000  
Tax Credit Carryforward, Amount 1,400,000  
Deferred Tax Assets, Valuation Allowance 28,200,857 20,886,811
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount 7,300,000 $ 9,200,000
Operating Loss Carry forwards Limitations On Use Amount 1,100,000  
Operating Loss Carry forwards Preownership Change Amount 20,200,000  
Operating Loss Forgive Pre ownership Change Amount 5,500,000  
Tax Credit Carryforward Preownership Change Amount 1,200,000  
Employee Service Share-based Compensation, Tax Benefit Realized from Exercise of Stock Options 568,000  
Orphan Drug Credit [Member]    
Income Taxes [Line Items]    
Tax Credit Carryforward, Amount $ 486,000  
U.S. Federal [Member]    
Income Taxes [Line Items]    
Operating Loss Carry forwards Expiration Date1 Approximately $10.2 million of the NOLs will begin to expire in 2023 with the balance expiring from 2024 through 2035  
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent 34.00%  
U.S. Federal [Member] | Research and Development Expense [Member]    
Income Taxes [Line Items]    
Tax Credit Carryforward, Description expire in 2033 through 2035  
State And Local [Member]    
Income Taxes [Line Items]    
Operating Loss Carryforwards $ 65,900,000  
Operating Loss Carry forwards Expiration Date1 Approximately $12.4 million of the Company's state NOLs expire in 2018 with the remaining balance expiring from 2019 through 2030  
State And Local [Member] | Research and Development Expense [Member]    
Income Taxes [Line Items]    
Tax Credit Carryforward, Amount $ 689,000  
Tax Credit Carryforward, Description expire in 2023 through 2029