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Contractual Agreements (Details Narrative) - USD ($) | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2021 | Jun. 30, 2020 | Jun. 30, 2021 | Jun. 30, 2020
Entity Listings [Line Items] |  |  |  |
Contract research and development expenses | $ 786,000 | $ 1,200,000 | $ 1,700,000 | $ 2,900,000
Abbott Products Inc [Member] | Collaborative Arrangement [Member] |  |  |  |
Entity Listings [Line Items] |  |  |  |
Percentage of net sales |  |  | 1.00% |
Royalties, commitment amount | $ 1,000,000.0 |  | $ 1,000,000.0 |
Percentage of royalties reduction based upon product launch |  |  | 50.00% |

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- Definition The costs incurred in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, excluding in-process research and development acquired in a business combination consummated during the period. Excludes software research and development, which has a separate concept. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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- Definition The amount the entity has committed to make for future royalty guarantees. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 928 -SubTopic 440 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6473578&loc=d3e63223-108013 + Details
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