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Schedule of Deferred Tax Assets and Liabilities (Details) - USD ($) | Dec. 31, 2021 | Dec. 31, 2020
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Income Tax Disclosure [Abstract] |  |
Stock-based compensation | $ 1,687,480 | $ 1,651,482
Net operating loss carryforwards | 34,759,890 | 35,102,326
Employee benefits | 56,009 | 54,108
Research and development tax credits | 4,935,609 | 4,472,003
Orphan drug tax credits | 1,186,582 | 1,168,828
Plant and equipment |  | 959
Other deductible tempory differences | 394,636 | 5,386
Total gross deferred tax assets | 43,020,206 | 42,455,092
Plant and equipment | (1,871) |
Total gross deferred tax liabilities | (1,871) |
Net deferred tax liabilities | (1,871) |
Deferred tax asset/deferred tax liability | 43,018,335 | 42,455,092
Less valuation allowance | (43,018,335) | (42,455,092)
Net deferred tax assets |  |

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