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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Schedule of Income Tax Expense

Income tax expense consists of:

 Schedule of Income Tax Expense

		December 31,
		2021				2020
U.S. federal		$	-			$	-
State and local			200				200
Deferred			-				-
Total		$	200			$	200

Schedule of Pretax Income from Continuing Operations

 Schedule of Pretax Income from Continuing Operations

		December 31,
		2021				2020
Computed “expected” tax benefit		$	(133,182	)		$	(4,402,570	)
Increase (reduction) in income taxes resulting from:
Change in valuation allowance			476,431				4,248,002
State and local income taxes, net of federal income tax benefit			158				158
Stock expense			97,697				86,209
Research and development tax credits			(352,163	)			(485,254	)
Orphan drug tax credit			(14,025	)			(4,797	)
Warrant liability			(74,737	)			607,360
Other, net			21				(48,908	)
Total		$	200			$	200

Schedule of Deferred Tax Assets and Liabilities

The tax effects of temporary differences that give rise to significant portions of the deferred tax assets and deferred tax liabilities at December 31, 2021 and 2020 are presented below.

Schedule of Deferred Tax Assets and Liabilities

		December 31,
		2021				2020
Deferred tax assets:
Stock-based compensation		$	1,687,480			$	1,651,482
Net operating loss carryforwards			34,759,890				35,102,326
Employee benefits			56,009				54,108
Research and development tax credits			4,935,609				4,472,003
Orphan drug tax credits			1,186,582				1,168,828
Plant and equipment			-				959
Other deductible tempory differences			394,636				5,386
Total gross deferred tax assets			43,020,206				42,455,092
Deferred tax assets:
Plant and equipment			(1,871	)			-
Total gross deferred tax liabilities			(1,871	)			-
Net deferred tax liabilities		$	(1,871	)		$	-
Deferred tax asset/deferred tax liability			43,018,335				42,455,092
Less valuation allowance			(43,018,335	)			(42,455,092	)
Net deferred tax assets		$	-			$	-

Schedule of Reconciliation of the Beginning and Ending Amount of Total Unrecognized Tax Contingencies, Excluding Interest and Penalties

A reconciliation of the beginning and ending amount of total unrecognized tax contingencies, excluding interest and penalties, for the years ended December 31, 2021 and 2020 are as follows:

Schedule of Reconciliation of the Beginning and Ending Amount of Total Unrecognized Tax Contingencies, Excluding Interest and Penalties

		December 31,
		2021				2020
Balance, beginning of year		$	-			$	-
Balance, end of year		$	-			$	-

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Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of the change in unrecognized tax benefits.

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