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Income Taxes (Details Narrative) - USD ($)
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Operating Loss Carryforwards [Line Items]    
Income Tax Expense (Benefit) $ 200 $ 200
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent 21.00% 21.00%
Deferred Tax Assets, Valuation Allowance $ 43,018,335 $ 42,455,092
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount 500,000 $ 5,200,000
Operating Loss Carry forwards Limitations On Use Amount 1,100,000  
Operating Loss Carry forwards Pre-ownership Change Amount 20,200,000  
Operating Loss Forgive Pre-ownership Change Amount 5,500,000  
Tax Credit Carryforward Pre-ownership Change Amount 1,200,000  
Operating Loss Carryforwards 135,600,000  
Tax Credit Carryforward, Amount $ 3,500,000  
Operating Loss Carry forwards Expiration Date1 Approximately $24.6 million of the NOL will expire between 2023 and 2033 and $70.8 million of the NOL will expire 2034 through 2037. Pursuant to the Tax Cuts and Jobs Act of 2017, NOL’s generated in 2018 and subsequent years have an unlimited carryforward therefore the 2020, 2019 and 2018 NOL of $40.2 million can be carried forward indefinitely. The research and development credits will begin to expire in 2033 through 2041.  
State and Local Jurisdiction [Member]    
Operating Loss Carryforwards [Line Items]    
Operating Loss Carryforwards $ 127,100,000  
Tax Credit Carryforward, Amount $ 1,400,000  
Operating Loss Carry forwards Expiration Date1 approximately $127.1 million and $1.4 million, respectively. None of the Company’s state NOL expires in 2022, $34.8 million expires between 2022 and 2029, and $92.3 million will expire in 2030 through 2036  
Tax Credit Carryforward, Description expire in 2023 through 2035  
Research and Development Expense [Member] | State and Local Jurisdiction [Member]    
Operating Loss Carryforwards [Line Items]    
Tax Credit Carryforward, Amount $ 1,200,000  
Tax Credit Carryforward, Description expire 2034 through 2037  
Research and Development Expense [Member] | Us Federal [Member]    
Operating Loss Carryforwards [Line Items]    
Tax Credit Carryforward, Description expire in 2033 through 2041